Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment

Ilaria Marech, Christian Leporini, Michele Ammendola, Mariangela Porcelli, Cosmo Damiano Gadaleta, Emilio Russo, Giovambattista De Sarro, Girolamo Ranieri

Research output: Contribution to journalArticle

Abstract

Angiogenesis is sustained by classical and non-classical proangiogenic factors (PFs) acting in tumor microenvironment and these factors are also potential targets of antiangiogenic therapies. All PFs induce the overexpression of several signaling pathways that lead to migration and proliferation of endothelial cells contributing to tumor angiogenesis and survival of cancer cells. In this review, we have analyzed each PF with its specific receptor/s and we have summarized the available antiangiogenic drugs (e.g. monoclonal antibodies) targeting these PFs, some of these agents have already been approved, others are currently in development for the treatment of several human malignancies.

Original languageEnglish
JournalCancer Letters
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Cancer
  • Endothelial cells
  • Novel antiangiogenic therapies
  • Proangiogenic factors
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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