Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia, Giuseppe Puccio, Francesco Locatelli, Mariarita Vetro, Marta Pillon, Angela Trizzino, Alessandra Sala, Salvatore Buffardi, Alberto Garaventa, Francesca Rossi, Maurizio Bianchi, Marco Zecca, Andrea Pession, Claudio Favre, Salvatore D’Amico, Massimo Provenzi, Giulio Andrea Zanazzo, Antonella Sau, Nicola Santoro, Rosamaria MuraCaterina Elia, Tommaso Casini, Maurizio Mascarin, Roberta Burnelli

Research output: Contribution to journalArticle

Abstract

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

Original languageEnglish
JournalLeukemia and Lymphoma
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • chemotherapeutic approaches
  • Lymphoma and Hodgkin disease
  • pediatric

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Farruggia, P., Puccio, G., Locatelli, F., Vetro, M., Pillon, M., Trizzino, A., Sala, A., Buffardi, S., Garaventa, A., Rossi, F., Bianchi, M., Zecca, M., Pession, A., Favre, C., D’Amico, S., Provenzi, M., Zanazzo, G. A., Sau, A., Santoro, N., ... Burnelli, R. (Accepted/In press). Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience. Leukemia and Lymphoma. https://doi.org/10.1080/10428194.2018.1493732