Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia; Giuseppe Puccio; Francesco Locatelli; Mariarita Vetro; Marta Pillon; Angela Trizzino; Alessandra Sala; Salvatore Buffardi; Alberto Garaventa; Francesca Rossi; Maurizio Bianchi; Marco Zecca; Andrea Pession; Claudio Favre; Salvatore D'Amico; Massimo Provenzi; Giulio Andrea Zanazzo; Antonella Sau; Nicola Santoro; Rosamaria Mura; Caterina Elia; Tommaso Casini; Maurizio Mascarin; Roberta Burnelli

doi:10.1080/10428194.2018.1493732

Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia, Giuseppe Puccio, Francesco Locatelli, Mariarita Vetro, Marta Pillon, Angela Trizzino, Alessandra Sala, Salvatore Buffardi, Alberto Garaventa, Francesca Rossi, Maurizio Bianchi, Marco Zecca, Andrea Pession, Claudio Favre, Salvatore D'Amico, Massimo Provenzi, Giulio Andrea Zanazzo, Antonella Sau, Nicola Santoro, Rosamaria MuraCaterina Elia, Tommaso Casini, Maurizio Mascarin, Roberta Burnelli

Research output: Contribution to journal › Article › peer-review

Abstract

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Leukemia and Lymphoma
DOIs	https://doi.org/10.1080/10428194.2018.1493732
Publication status	E-pub ahead of print - Oct 10 2018

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Farruggia, P., Puccio, G., Locatelli, F., Vetro, M., Pillon, M., Trizzino, A., Sala, A., Buffardi, S., Garaventa, A., Rossi, F., Bianchi, M., Zecca, M., Pession, A., Favre, C., D'Amico, S., Provenzi, M., Zanazzo, G. A., Sau, A., Santoro, N., ... Burnelli, R. (2018). Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience. Leukemia and Lymphoma, 1-7. https://doi.org/10.1080/10428194.2018.1493732

Classical pediatric Hodgkin lymphoma in very young patients : the Italian experience. / Farruggia, Piero; Puccio, Giuseppe; Locatelli, Francesco; Vetro, Mariarita; Pillon, Marta; Trizzino, Angela; Sala, Alessandra; Buffardi, Salvatore; Garaventa, Alberto ; Rossi, Francesca; Bianchi, Maurizio; Zecca, Marco; Pession, Andrea; Favre, Claudio; D'Amico, Salvatore; Provenzi, Massimo; Zanazzo, Giulio Andrea; Sau, Antonella; Santoro, Nicola; Mura, Rosamaria; Elia, Caterina; Casini, Tommaso; Mascarin, Maurizio; Burnelli, Roberta.

In: Leukemia and Lymphoma, 10.10.2018, p. 1-7.

Research output: Contribution to journal › Article › peer-review

Farruggia, P, Puccio, G, Locatelli, F, Vetro, M, Pillon, M, Trizzino, A, Sala, A, Buffardi, S, Garaventa, A , Rossi, F, Bianchi, M, Zecca, M, Pession, A, Favre, C, D'Amico, S, Provenzi, M, Zanazzo, GA, Sau, A, Santoro, N, Mura, R, Elia, C, Casini, T, Mascarin, M & Burnelli, R 2018, 'Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience', Leukemia and Lymphoma, pp. 1-7. https://doi.org/10.1080/10428194.2018.1493732

Farruggia, Piero ; Puccio, Giuseppe ; Locatelli, Francesco ; Vetro, Mariarita ; Pillon, Marta ; Trizzino, Angela ; Sala, Alessandra ; Buffardi, Salvatore ; Garaventa, Alberto ; Rossi, Francesca ; Bianchi, Maurizio ; Zecca, Marco ; Pession, Andrea ; Favre, Claudio ; D'Amico, Salvatore ; Provenzi, Massimo ; Zanazzo, Giulio Andrea ; Sau, Antonella ; Santoro, Nicola ; Mura, Rosamaria ; Elia, Caterina ; Casini, Tommaso ; Mascarin, Maurizio ; Burnelli, Roberta. / Classical pediatric Hodgkin lymphoma in very young patients : the Italian experience. In: Leukemia and Lymphoma. 2018 ; pp. 1-7.

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title = "Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience",

abstract = "Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.",

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AU - Farruggia, Piero

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AU - Locatelli, Francesco

AU - Vetro, Mariarita

AU - Pillon, Marta

AU - Trizzino, Angela

AU - Sala, Alessandra

AU - Buffardi, Salvatore

AU - Garaventa, Alberto

AU - Rossi, Francesca

AU - Bianchi, Maurizio

AU - Zecca, Marco

AU - Pession, Andrea

AU - Favre, Claudio

AU - D'Amico, Salvatore

AU - Provenzi, Massimo

AU - Zanazzo, Giulio Andrea

AU - Sau, Antonella

AU - Santoro, Nicola

AU - Mura, Rosamaria

AU - Elia, Caterina

AU - Casini, Tommaso

AU - Mascarin, Maurizio

AU - Burnelli, Roberta

PY - 2018/10/10

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N2 - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

AB - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

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