TY - JOUR
T1 - Classical pediatric Hodgkin lymphoma in very young patients
T2 - the Italian experience
AU - Farruggia, Piero
AU - Puccio, Giuseppe
AU - Locatelli, Francesco
AU - Vetro, Mariarita
AU - Pillon, Marta
AU - Trizzino, Angela
AU - Sala, Alessandra
AU - Buffardi, Salvatore
AU - Garaventa, Alberto
AU - Rossi, Francesca
AU - Bianchi, Maurizio
AU - Zecca, Marco
AU - Pession, Andrea
AU - Favre, Claudio
AU - D'Amico, Salvatore
AU - Provenzi, Massimo
AU - Zanazzo, Giulio Andrea
AU - Sau, Antonella
AU - Santoro, Nicola
AU - Mura, Rosamaria
AU - Elia, Caterina
AU - Casini, Tommaso
AU - Mascarin, Maurizio
AU - Burnelli, Roberta
PY - 2018/10/10
Y1 - 2018/10/10
N2 - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.
AB - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p = .0451) and PFS (p = .00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p = .0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.
U2 - 10.1080/10428194.2018.1493732
DO - 10.1080/10428194.2018.1493732
M3 - Article
C2 - 30301436
SP - 1
EP - 7
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
ER -