Classification and biology of tumour associated stromal cells

Lizzia Raffaghello, Francesco Dazzi

Research output: Contribution to journalArticle

Abstract

Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalImmunology Letters
Volume168
Issue number2
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • Cancer associated fibroblasts
  • Fibrocytes
  • Mesenchymal stem cells
  • Tumor stroma

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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