The prognostic significance of clinical and histopathologic factors was analysed in a consecutive series of 51 patients with biliary tract and gallbladder cancer, who were operated in Morgagni Hospital in Forrì from 1993 to 2000. The median follow-up was 75 months, with a median survival of 9 months and a one-year overall survival of 34%. The following clinico-pathologic parameters were evaluated in univariate analysis: sex, age, site of disease, histotype, grading and proliferative index (Mib1). Patients were prevalently between 70 and 80 years of age. Fifty per cent of tumours involved the biliary tract, with a male/female ratio of 1.2/1, and 44% the gallbladder, with a male/female ratio of 1/2.8. Most tumours were sited in the proximal/middle third and were mainly papillary adenocarcinomas. Mucinous or squamous cell forms and cholangiocarcinomas were rarely observed. The majority of tumours were grade II-III. For biliary tract tumours, univariate analysis highlighted 3 factors correlated with the clinical course of the disease: site (p = 0.008), histotype (p = 0.03) and grading (p = 0.03). In contrast, the only statistically significant parameter observed for gallbladder tumours was histotype (p = 0.03).
|Translated title of the contribution||Classification and characterization of bile duct tumours|
|Number of pages||4|
|Journal||European Journal of Oncology|
|Publication status||Published - Jun 2002|
ASJC Scopus subject areas
- Cancer Research