Classification of amyotrophic lateral sclerosis cases at presentation in epidemiological studies

S. Zoccolella, E. Beghi, L. Serlenga, G. Logroscino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) diagnosis is based exclusively on clinical grounds because of the absence of biological markers and of specific neuroradiological and neurophysiological diagnostic features. A clinical classification system of cases has been introduced (El Escorial Criteria, EEC) and then revised after the inclusion of the neurophysiologic assessment (Airlie House Criteria, AHC) for enrolment of patients in clinical trials. The aim of this study is to present cases at presentation in the early stages of the disease that have difficult allocation both in EEC and AHC. All cases were subjects enrolled through SLAP, a population-based registry based in Puglia, Southern Italy. Although differential diagnosis excluded ALS-mimic syndromes, we identified four cases (out of 130 cases, 3.1%) that did not meet the EEC and AHC at the first visit. Even though the number of unclassifiable cases is small, both EEC and AHC may be restrictive. This precludes the enrolment of ALS cases at an early stage both in observational studies and clinical trials.

Original languageEnglish
Pages (from-to)330-333
Number of pages4
JournalNeurological Sciences
Volume26
Issue number5
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Amyotrophic Lateral Sclerosis
Epidemiologic Studies
Clinical Trials
Italy
Observational Studies
Registries
Differential Diagnosis
Biomarkers
Population

Keywords

  • Amyotrophic lateral sclerosis
  • El Escorial criteria
  • Suspect ALS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Classification of amyotrophic lateral sclerosis cases at presentation in epidemiological studies. / Zoccolella, S.; Beghi, E.; Serlenga, L.; Logroscino, G.

In: Neurological Sciences, Vol. 26, No. 5, 12.2005, p. 330-333.

Research output: Contribution to journalArticle

Zoccolella, S. ; Beghi, E. ; Serlenga, L. ; Logroscino, G. / Classification of amyotrophic lateral sclerosis cases at presentation in epidemiological studies. In: Neurological Sciences. 2005 ; Vol. 26, No. 5. pp. 330-333.
@article{f862efc852e741b0989943aca882e85e,
title = "Classification of amyotrophic lateral sclerosis cases at presentation in epidemiological studies",
abstract = "Amyotrophic lateral sclerosis (ALS) diagnosis is based exclusively on clinical grounds because of the absence of biological markers and of specific neuroradiological and neurophysiological diagnostic features. A clinical classification system of cases has been introduced (El Escorial Criteria, EEC) and then revised after the inclusion of the neurophysiologic assessment (Airlie House Criteria, AHC) for enrolment of patients in clinical trials. The aim of this study is to present cases at presentation in the early stages of the disease that have difficult allocation both in EEC and AHC. All cases were subjects enrolled through SLAP, a population-based registry based in Puglia, Southern Italy. Although differential diagnosis excluded ALS-mimic syndromes, we identified four cases (out of 130 cases, 3.1{\%}) that did not meet the EEC and AHC at the first visit. Even though the number of unclassifiable cases is small, both EEC and AHC may be restrictive. This precludes the enrolment of ALS cases at an early stage both in observational studies and clinical trials.",
keywords = "Amyotrophic lateral sclerosis, El Escorial criteria, Suspect ALS",
author = "S. Zoccolella and E. Beghi and L. Serlenga and G. Logroscino",
year = "2005",
month = "12",
doi = "10.1007/s10072-005-0501-y",
language = "English",
volume = "26",
pages = "330--333",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "5",

}

TY - JOUR

T1 - Classification of amyotrophic lateral sclerosis cases at presentation in epidemiological studies

AU - Zoccolella, S.

AU - Beghi, E.

AU - Serlenga, L.

AU - Logroscino, G.

PY - 2005/12

Y1 - 2005/12

N2 - Amyotrophic lateral sclerosis (ALS) diagnosis is based exclusively on clinical grounds because of the absence of biological markers and of specific neuroradiological and neurophysiological diagnostic features. A clinical classification system of cases has been introduced (El Escorial Criteria, EEC) and then revised after the inclusion of the neurophysiologic assessment (Airlie House Criteria, AHC) for enrolment of patients in clinical trials. The aim of this study is to present cases at presentation in the early stages of the disease that have difficult allocation both in EEC and AHC. All cases were subjects enrolled through SLAP, a population-based registry based in Puglia, Southern Italy. Although differential diagnosis excluded ALS-mimic syndromes, we identified four cases (out of 130 cases, 3.1%) that did not meet the EEC and AHC at the first visit. Even though the number of unclassifiable cases is small, both EEC and AHC may be restrictive. This precludes the enrolment of ALS cases at an early stage both in observational studies and clinical trials.

AB - Amyotrophic lateral sclerosis (ALS) diagnosis is based exclusively on clinical grounds because of the absence of biological markers and of specific neuroradiological and neurophysiological diagnostic features. A clinical classification system of cases has been introduced (El Escorial Criteria, EEC) and then revised after the inclusion of the neurophysiologic assessment (Airlie House Criteria, AHC) for enrolment of patients in clinical trials. The aim of this study is to present cases at presentation in the early stages of the disease that have difficult allocation both in EEC and AHC. All cases were subjects enrolled through SLAP, a population-based registry based in Puglia, Southern Italy. Although differential diagnosis excluded ALS-mimic syndromes, we identified four cases (out of 130 cases, 3.1%) that did not meet the EEC and AHC at the first visit. Even though the number of unclassifiable cases is small, both EEC and AHC may be restrictive. This precludes the enrolment of ALS cases at an early stage both in observational studies and clinical trials.

KW - Amyotrophic lateral sclerosis

KW - El Escorial criteria

KW - Suspect ALS

UR - http://www.scopus.com/inward/record.url?scp=30744438326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30744438326&partnerID=8YFLogxK

U2 - 10.1007/s10072-005-0501-y

DO - 10.1007/s10072-005-0501-y

M3 - Article

C2 - 16388367

AN - SCOPUS:30744438326

VL - 26

SP - 330

EP - 333

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 5

ER -