TY - JOUR
T1 - Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics
AU - Colombini, Alessandra
AU - Galbusera, Fabio
AU - Cortese, Maria Cristina
AU - Gallazzi, Enrico
AU - Viganò, Marco
AU - Albano, Domenico
AU - Cauci, Sabina
AU - Sconfienza, Luca Maria
AU - Brayda-Bruno, Marco
N1 - Funding Information:
This research was funded by the Italian Ministry of Health, “Ricerca Corrente”.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Purpose: To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls. Methods: In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables. Results: Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males). Conclusions: The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.
AB - Purpose: To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls. Methods: In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables. Results: Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males). Conclusions: The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.
KW - Collagen
KW - Endplate lesions
KW - Lumbar spine
KW - Risk factors
KW - Vitamin D receptor polymorphisms
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U2 - 10.1007/s00586-021-06719-1
DO - 10.1007/s00586-021-06719-1
M3 - Article
C2 - 33452926
AN - SCOPUS:85100065576
SP - 2231
EP - 2237
JO - European Spine Journal
JF - European Spine Journal
SN - 0940-6719
ER -