Classification of healthy, Alzheimer's disease, and Parkinson's disease individuals with cortical generators of rsEEG rhythms

C. Del Percio, L. Bonanni, F. Stocchi, C. Babiloni, R. Lizio, M. T. Pascarelli, G. Noce, A. Soricelli, R. Ferri, F. M. Nobili, R. Giubilei, C. De Lena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the present study, we verified the working hypothesis that cortical generators of resting state eyes-closed electroencephalographic (rsEEG) rhythms could classify with good performance (area under receiver operating characteristic, AUROC > 0.8) healthy elderly (Nold), Alzheimer's disease (AD) and Parkinson's disease (PD) individuals. rsEEG recordings were performed in 110 AD, 110 PD, and 75 Nold patients. Individual delta, theta, low-frequency alpha, and high-frequency bands were measured. Fixed low-frequency beta and high-frequency beta were also evaluated. eLORETA freeware measured cortical generators of rsEEG rhythms from posterior sources. Classification analysis was performed with the ROC curve. Cortical generators of posterior rsEEG rhythms at delta, theta, low-frequency alpha, high-frequency alpha, low-frequency beta, and high-frequency beta allowed a good performance (AUROC > 0.8) in the classification between healthy and neurodegenerative (i.e., AD and PD) individuals. Moreover, cortical generators of posterior rsEEG rhythms at low-frequency alpha permitted only a moderate performance (AUROC > 0.75) in the classification between AD and PD individuals. Future prospective cross-validation studies will have to test these candidate rsEEG markers for clinical applications and drug discovery.

Original languageEnglish
Title of host publication2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1270-1275
Number of pages6
ISBN (Electronic)9781728145693
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019 - Bari, Italy
Duration: Oct 6 2019Oct 9 2019

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume2019-October
ISSN (Print)1062-922X

Conference

Conference2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019
CountryItaly
CityBari
Period10/6/1910/9/19

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Control and Systems Engineering
  • Human-Computer Interaction

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