TY - JOUR
T1 - Classification of single normal and Alzheimer's disease individuals from cortical sources of resting state EEG rhythms
AU - Babiloni, Claudio
AU - Triggiani, Antonio I.
AU - Lizio, Roberta
AU - Cordone, Susanna
AU - Tattoli, Giacomo
AU - Bevilacqua, Vitoantonio
AU - Soricelli, Andrea
AU - Ferri, Raffaele
AU - Nobili, Flavio
AU - Gesualdo, Loreto
AU - Millán-Calenti, José C.
AU - Buján, Ana
AU - Tortelli, Rosanna
AU - Cardinali, Valentina
AU - Barulli, Maria Rosaria
AU - Giannini, Antonio
AU - Spagnolo, Pantaleo
AU - Armenise, Silvia
AU - Buenza, Grazia
AU - Scianatico, Gaetano
AU - Logroscino, Giancarlo
AU - Frisoni, Giovanni B.
AU - Del Percio, Claudio
PY - 2016/2/23
Y1 - 2016/2/23
N2 - Previous studies have shown abnormal power and functional connectivity of resting state electroencephalographic (EEG) rhythms in groups of Alzheimer's disease (AD) compared to healthy elderly (Nold) subjects. Here we tested the best classification rate of 120 AD patients and 100 matched Nold subjects using EEG markers based on cortical sources of power and functional connectivity of these rhythms. EEG data were recorded during resting state eyes-closed condition. Exact low-resolution brain electromagnetic tomography (eLORETA) estimated the power and functional connectivity of cortical sources in frontal, central, parietal, occipital, temporal, and limbic regions. Delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz) were the frequency bands of interest. The classification rates of interest were those with an area under the receiver operating characteristic curve (AUROC) higher than 0.7 as a threshold for a moderate classification rate (i.e., 70%). Results showed that the following EEG markers overcame this threshold: (i) central, parietal, occipital, temporal, and limbic delta/alpha 1 current density; (ii) central, parietal, occipital temporal, and limbic delta/alpha 2 current density; (iii) frontal theta/alpha 1 current density; (iv) occipital delta/alpha 1 inter-hemispherical connectivity; (v) occipital-temporal theta/alpha 1 right and left intra-hemispherical connectivity; and (vi) parietal-limbic alpha 1 right intra-hemispherical connectivity. Occipital delta/alpha 1 current density showed the best classification rate (sensitivity of 73.3%, specificity of 78%, accuracy of 75.5%, and AUROC of 82%). These results suggest that EEG source markers can classify Nold and AD individuals with a moderate classification rate higher than 80%.
AB - Previous studies have shown abnormal power and functional connectivity of resting state electroencephalographic (EEG) rhythms in groups of Alzheimer's disease (AD) compared to healthy elderly (Nold) subjects. Here we tested the best classification rate of 120 AD patients and 100 matched Nold subjects using EEG markers based on cortical sources of power and functional connectivity of these rhythms. EEG data were recorded during resting state eyes-closed condition. Exact low-resolution brain electromagnetic tomography (eLORETA) estimated the power and functional connectivity of cortical sources in frontal, central, parietal, occipital, temporal, and limbic regions. Delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz) were the frequency bands of interest. The classification rates of interest were those with an area under the receiver operating characteristic curve (AUROC) higher than 0.7 as a threshold for a moderate classification rate (i.e., 70%). Results showed that the following EEG markers overcame this threshold: (i) central, parietal, occipital, temporal, and limbic delta/alpha 1 current density; (ii) central, parietal, occipital temporal, and limbic delta/alpha 2 current density; (iii) frontal theta/alpha 1 current density; (iv) occipital delta/alpha 1 inter-hemispherical connectivity; (v) occipital-temporal theta/alpha 1 right and left intra-hemispherical connectivity; and (vi) parietal-limbic alpha 1 right intra-hemispherical connectivity. Occipital delta/alpha 1 current density showed the best classification rate (sensitivity of 73.3%, specificity of 78%, accuracy of 75.5%, and AUROC of 82%). These results suggest that EEG source markers can classify Nold and AD individuals with a moderate classification rate higher than 80%.
KW - Alpha rhythms
KW - Alzheimer's disease (AD)
KW - Area under the receiver operating characteristic curve (AUROC)
KW - Delta rhythms
KW - Electroencephalography (EEG)
KW - Exact low-resolution brain electromagnetic tomography (eLORETA)
KW - Lagged linear connectivity
KW - Spectral coherence
UR - http://www.scopus.com/inward/record.url?scp=84964378023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964378023&partnerID=8YFLogxK
U2 - 10.3389/fnins.2016.00047
DO - 10.3389/fnins.2016.00047
M3 - Article
AN - SCOPUS:84964378023
VL - 10
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
SN - 1662-4548
IS - FEB
M1 - 47
ER -