Clear cell and papillary serous endometrial carcinomas: Survival in a series of 128 cases

Giovanna Scarfone, Rita Secomandi, Fabio Parazzini, Riccardo Viganò, Giorgia Mangili, Luigi Frigerio, Antonella Villa, Saverio Tateo, Elena Ricci, Giorgio Bolis

Research output: Contribution to journalArticle

Abstract

Purpose: Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients' survival in a retrospective series of 128 CC and PS endometrial cancer cases. Methods: All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 %) were PS endometrial cancer cases, 45 (35.2 %) CC cases and 6 (4.6 %) cases had mixed CC and PS histotype. Results: 54 (42 %) cases were diagnosed at stage I, 10 (8 %) at stage II, 47 (37 %) at stage III and 17 (13 %) at stage IV. Recurrence was observed in 49 cases (38.3 %). The median time at recurrence was 12 months (interquartile range 7-18). The rate of recurrence was 20.3 % in cases at stage I-lI and 56.2 % in cases at stage III-IV (p <0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 % (14 cases) in CC cases, 43.1 % (31 cases) in PS cases and 66.7 % (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 % (67.4 % for CC cases, 55.1 % for PS and mixed cases). Conclusion: In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 % and the 5-year progression-free survival was 59.5 %.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume287
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Papillary Carcinoma
Endometrial Neoplasms
Survival
Recurrence
Disease-Free Survival
Survival Analysis
Pelvis
Italy

Keywords

  • Endometrial cancer
  • Histotype
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Clear cell and papillary serous endometrial carcinomas : Survival in a series of 128 cases. / Scarfone, Giovanna; Secomandi, Rita; Parazzini, Fabio; Viganò, Riccardo; Mangili, Giorgia; Frigerio, Luigi; Villa, Antonella; Tateo, Saverio; Ricci, Elena; Bolis, Giorgio.

In: Archives of Gynecology and Obstetrics, Vol. 287, No. 2, 02.2013, p. 351-356.

Research output: Contribution to journalArticle

Scarfone, Giovanna ; Secomandi, Rita ; Parazzini, Fabio ; Viganò, Riccardo ; Mangili, Giorgia ; Frigerio, Luigi ; Villa, Antonella ; Tateo, Saverio ; Ricci, Elena ; Bolis, Giorgio. / Clear cell and papillary serous endometrial carcinomas : Survival in a series of 128 cases. In: Archives of Gynecology and Obstetrics. 2013 ; Vol. 287, No. 2. pp. 351-356.
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abstract = "Purpose: Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients' survival in a retrospective series of 128 CC and PS endometrial cancer cases. Methods: All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 {\%}) were PS endometrial cancer cases, 45 (35.2 {\%}) CC cases and 6 (4.6 {\%}) cases had mixed CC and PS histotype. Results: 54 (42 {\%}) cases were diagnosed at stage I, 10 (8 {\%}) at stage II, 47 (37 {\%}) at stage III and 17 (13 {\%}) at stage IV. Recurrence was observed in 49 cases (38.3 {\%}). The median time at recurrence was 12 months (interquartile range 7-18). The rate of recurrence was 20.3 {\%} in cases at stage I-lI and 56.2 {\%} in cases at stage III-IV (p <0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 {\%} (14 cases) in CC cases, 43.1 {\%} (31 cases) in PS cases and 66.7 {\%} (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 {\%} (67.4 {\%} for CC cases, 55.1 {\%} for PS and mixed cases). Conclusion: In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 {\%} and the 5-year progression-free survival was 59.5 {\%}.",
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T2 - Survival in a series of 128 cases

AU - Scarfone, Giovanna

AU - Secomandi, Rita

AU - Parazzini, Fabio

AU - Viganò, Riccardo

AU - Mangili, Giorgia

AU - Frigerio, Luigi

AU - Villa, Antonella

AU - Tateo, Saverio

AU - Ricci, Elena

AU - Bolis, Giorgio

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N2 - Purpose: Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients' survival in a retrospective series of 128 CC and PS endometrial cancer cases. Methods: All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 %) were PS endometrial cancer cases, 45 (35.2 %) CC cases and 6 (4.6 %) cases had mixed CC and PS histotype. Results: 54 (42 %) cases were diagnosed at stage I, 10 (8 %) at stage II, 47 (37 %) at stage III and 17 (13 %) at stage IV. Recurrence was observed in 49 cases (38.3 %). The median time at recurrence was 12 months (interquartile range 7-18). The rate of recurrence was 20.3 % in cases at stage I-lI and 56.2 % in cases at stage III-IV (p <0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 % (14 cases) in CC cases, 43.1 % (31 cases) in PS cases and 66.7 % (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 % (67.4 % for CC cases, 55.1 % for PS and mixed cases). Conclusion: In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 % and the 5-year progression-free survival was 59.5 %.

AB - Purpose: Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients' survival in a retrospective series of 128 CC and PS endometrial cancer cases. Methods: All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 %) were PS endometrial cancer cases, 45 (35.2 %) CC cases and 6 (4.6 %) cases had mixed CC and PS histotype. Results: 54 (42 %) cases were diagnosed at stage I, 10 (8 %) at stage II, 47 (37 %) at stage III and 17 (13 %) at stage IV. Recurrence was observed in 49 cases (38.3 %). The median time at recurrence was 12 months (interquartile range 7-18). The rate of recurrence was 20.3 % in cases at stage I-lI and 56.2 % in cases at stage III-IV (p <0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 % (14 cases) in CC cases, 43.1 % (31 cases) in PS cases and 66.7 % (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 % (67.4 % for CC cases, 55.1 % for PS and mixed cases). Conclusion: In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 % and the 5-year progression-free survival was 59.5 %.

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