Clear cell carcinoid of the appendix: An uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis

Giulio Rossi, Nazarena Nannini, Federica Bertolini, Maria Cecilia Mengoli, Rita Fano, Alberto Cavazza

Research output: Contribution to journalArticlepeer-review

Abstract

The designation of clear cell/lipid-rich refers to an unusual variant of neuroendocrine tumor ("carcinoid") described in several organs, but only recently observed in the appendix. In this study, we report the morphologic, immunohistochemical, and ultrastructural features of an incidentally discovered appendiceal clear cell/lipid-rich carcinoid in a 32-year-old man without any evidence of von Hippel-Lindau disease. Differential diagnosis with mimicking neoplastic and non-tumor lesions, epidemiology, and clinical behavior of this exceedingly rare variant of carcinoid of the appendix are also discussed.

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalEndocrine Pathology
Volume21
Issue number4
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Appendix
  • Carcinoid
  • Clear cell
  • Electron microscopy
  • Immunohistochemistry
  • Lipid
  • Mesoappendix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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