TY - JOUR
T1 - Clear cell hidradenoma associated with the folliculo-sebaceous-apocrine unit
T2 - Histologic study of five cases
AU - Gianotti, Raffaele
AU - Alessi, Elvio
PY - 1997
Y1 - 1997
N2 - Hidradenomas are benign adnexal neoplasms of uncertain derivation. Although most investigators traditionally have considered these neoplasms to exhibit eccrine differentiation, with only occasional reports supporting apocrine derivation, subdivision of hidradenomas into two groups was recently suggested: those with eccrine differentiation (or poroid hidradenomas) and those exhibiting apocrine differentiation (or clear cell hidradenomas). We have observed five cases of clear cell hidradenomas manifesting unquestionable apocrine characteristics excised from sites other than the axilla, and displaying continuity with the epidermis through follicles. Because of the common embryologic derivation of apocrine glands, sebaceous glands, and hair follicles, and their histologic integration as the folliculo-sebaceous-apocrine unit, these findings suggest a possible origin of certain apocrine hidradenomas from pluripotential germinative cells present in follicles.
AB - Hidradenomas are benign adnexal neoplasms of uncertain derivation. Although most investigators traditionally have considered these neoplasms to exhibit eccrine differentiation, with only occasional reports supporting apocrine derivation, subdivision of hidradenomas into two groups was recently suggested: those with eccrine differentiation (or poroid hidradenomas) and those exhibiting apocrine differentiation (or clear cell hidradenomas). We have observed five cases of clear cell hidradenomas manifesting unquestionable apocrine characteristics excised from sites other than the axilla, and displaying continuity with the epidermis through follicles. Because of the common embryologic derivation of apocrine glands, sebaceous glands, and hair follicles, and their histologic integration as the folliculo-sebaceous-apocrine unit, these findings suggest a possible origin of certain apocrine hidradenomas from pluripotential germinative cells present in follicles.
KW - Apocrine
KW - Derivation
KW - Eccrine
KW - Hidradenoma
KW - Neoplasm
UR - http://www.scopus.com/inward/record.url?scp=0030711487&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030711487&partnerID=8YFLogxK
U2 - 10.1097/00000372-199708000-00006
DO - 10.1097/00000372-199708000-00006
M3 - Article
C2 - 9261469
AN - SCOPUS:0030711487
VL - 19
SP - 351
EP - 357
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 4
ER -