Clear cell hidradenoma associated with the folliculo-sebaceous-apocrine unit: Histologic study of five cases

Raffaele Gianotti, Elvio Alessi

Research output: Contribution to journalArticle

Abstract

Hidradenomas are benign adnexal neoplasms of uncertain derivation. Although most investigators traditionally have considered these neoplasms to exhibit eccrine differentiation, with only occasional reports supporting apocrine derivation, subdivision of hidradenomas into two groups was recently suggested: those with eccrine differentiation (or poroid hidradenomas) and those exhibiting apocrine differentiation (or clear cell hidradenomas). We have observed five cases of clear cell hidradenomas manifesting unquestionable apocrine characteristics excised from sites other than the axilla, and displaying continuity with the epidermis through follicles. Because of the common embryologic derivation of apocrine glands, sebaceous glands, and hair follicles, and their histologic integration as the folliculo-sebaceous-apocrine unit, these findings suggest a possible origin of certain apocrine hidradenomas from pluripotential germinative cells present in follicles.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalAmerican Journal of Dermatopathology
Volume19
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Apocrine
  • Derivation
  • Eccrine
  • Hidradenoma
  • Neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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