Clear cell odontogenic carcinoma: Report of two cases and review of the literature

Eugenio Maiorano, Mario Altini, Giuseppe Viale, Adriano Piattelli, Gianfranco Favia

Research output: Contribution to journalArticlepeer-review


This study reviews the literature and reports on the morphologic and immunophenotypic features of 2 clear cell odontogenic carcinomas occurring in the mandible of elderly women, showing extensive infiltration into adjacent tissues. The tumor cells were large, with clear cytoplasm, and arranged in irregular sheets. Some of the latter demonstrated a peripheral rim of cells with eosinophilic cytoplasm or included duct-like structures. There was no evidence of ameloblastic differentiation. Most cells contained glycogen granules and were immunoreactive for cytokeratins and epithelial membrane antigen. In the differential diagnosis other clear cell odontogenic, salivary gland, and metastatic tumors should be considered. Both cases were treated with surgical excision, and the patients are free of disease after 3 and 5 years, respectively. In the literature, however, variable behavior of these tumors has been reported, including recurrence and metastases. It is recommended that terms such as clear cell ameloblastoma and clear cell odontogenic tumor not be used to describe such tumors.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalAmerican Journal of Clinical Pathology
Issue number1
Publication statusPublished - Jul 2001


  • Clear cell ameloblastoma
  • Clear cell odontogenic carcinoma
  • Clear cell tumors
  • Immunohistochemistry
  • Odontogenic tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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