Clear cell (“sugar”) tumor of the lung is a lesion strictly related to angiomyolipoma — the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC)

F. Bonetti, M. Pea, G. Martignoni, C. Doglioni, G. Zamboni, P. Capelli, P. Rimondi, A. Andrion

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

We report a comparative study of 3 clear cell tumors of the lung (CCTL) and 3 angiomyolipomas (AML) of the kidney. Morpho-logical analysis shows that the cells of CCTL are identical to the perivascular epithelioid component of AML. Phenotypically they both consistently expressed melanoma-associated antigens recognized by Moabs HMB45 and HMSA-1, while they were negative for HMSA-5. A minority of cells also expressed S-100 protein, vimentin and actin. In addition, one case of CCTL showed mature adipose tissue entrapped in the proliferation, thus suggesting an intermediate form between CCTL and AML. Based on morphological and phenotypical similarities, it is suggested that CCTL and AML belong to the same family of lesions, characterized by the presence of a peculiar muscle cell, expressing different melanoma-associated antigens.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalPathology
Volume26
Issue number3
Publication statusPublished - 1994

Fingerprint

Perivascular Epithelioid Cell Neoplasms
Angiomyolipoma
Epithelioid Cells
Lung
Melanoma-Specific Antigens
Neoplasms
S100 Proteins
Vimentin
Muscle Cells
Adipose Tissue
Actins
Kidney

Keywords

  • Angiomyolipoma
  • Melanogenesis
  • Melanoma-associated antigens
  • Sugar tumor
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clear cell (“sugar”) tumor of the lung is a lesion strictly related to angiomyolipoma — the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC). / Bonetti, F.; Pea, M.; Martignoni, G.; Doglioni, C.; Zamboni, G.; Capelli, P.; Rimondi, P.; Andrion, A.

In: Pathology, Vol. 26, No. 3, 1994, p. 230-236.

Research output: Contribution to journalArticle

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AU - Pea, M.

AU - Martignoni, G.

AU - Doglioni, C.

AU - Zamboni, G.

AU - Capelli, P.

AU - Rimondi, P.

AU - Andrion, A.

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AB - We report a comparative study of 3 clear cell tumors of the lung (CCTL) and 3 angiomyolipomas (AML) of the kidney. Morpho-logical analysis shows that the cells of CCTL are identical to the perivascular epithelioid component of AML. Phenotypically they both consistently expressed melanoma-associated antigens recognized by Moabs HMB45 and HMSA-1, while they were negative for HMSA-5. A minority of cells also expressed S-100 protein, vimentin and actin. In addition, one case of CCTL showed mature adipose tissue entrapped in the proliferation, thus suggesting an intermediate form between CCTL and AML. Based on morphological and phenotypical similarities, it is suggested that CCTL and AML belong to the same family of lesions, characterized by the presence of a peculiar muscle cell, expressing different melanoma-associated antigens.

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