Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report

P. Monini; M. C. Sirianni; M. Franco; L. Vincenzi; S. Topino; D. Goletti; P. Leone; P. Leone; C. Chiozzini; E. Nicastri; M. Andreoni; O. Borduagni; C. Sgadari; G. Rezza; M. Stürzl; B. Ensoli

doi:10.1086/323982

Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report

P. Monini, M. C. Sirianni, M. Franco, L. Vincenzi, S. Topino, D. Goletti, P. Leone, P. Leone, C. Chiozzini, E. Nicastri, M. Andreoni, O. Borduagni, C. Sgadari, G. Rezza, M. Stürzl, B. Ensoli

Research output: Contribution to journal › Article › peer-review

Abstract

A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3⁺ and CD4⁺ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.

Original language	English
Pages (from-to)	1782-1785
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	33
Issue number	10
DOIs	https://doi.org/10.1086/323982
Publication status	Published - Nov 15 2001

ASJC Scopus subject areas

Immunology

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Monini, P., Sirianni, M. C., Franco, M., Vincenzi, L., Topino, S., Goletti, D., Leone, P., Leone, P., Chiozzini, C., Nicastri, E., Andreoni, M., Borduagni, O., Sgadari, C., Rezza, G., Stürzl, M., & Ensoli, B. (2001). Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report. Clinical Infectious Diseases, 33(10), 1782-1785. https://doi.org/10.1086/323982

Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy : A case report. / Monini, P.; Sirianni, M. C.; Franco, M.; Vincenzi, L.; Topino, S.; Goletti, D.; Leone, P.; Leone, P.; Chiozzini, C.; Nicastri, E.; Andreoni, M.; Borduagni, O.; Sgadari, C.; Rezza, G.; Stürzl, M.; Ensoli, B.

In: Clinical Infectious Diseases, Vol. 33, No. 10, 15.11.2001, p. 1782-1785.

Research output: Contribution to journal › Article › peer-review

Monini, P, Sirianni, MC, Franco, M, Vincenzi, L , Topino, S , Goletti, D, Leone, P, Leone, P, Chiozzini, C, Nicastri, E, Andreoni, M, Borduagni, O, Sgadari, C, Rezza, G, Stürzl, M & Ensoli, B 2001, 'Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report', Clinical Infectious Diseases, vol. 33, no. 10, pp. 1782-1785. https://doi.org/10.1086/323982

Monini, P. ; Sirianni, M. C. ; Franco, M. ; Vincenzi, L. ; Topino, S. ; Goletti, D. ; Leone, P. ; Leone, P. ; Chiozzini, C. ; Nicastri, E. ; Andreoni, M. ; Borduagni, O. ; Sgadari, C. ; Rezza, G. ; Stürzl, M. ; Ensoli, B. / Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy : A case report. In: Clinical Infectious Diseases. 2001 ; Vol. 33, No. 10. pp. 1782-1785.

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abstract = "A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.",

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