Abstract
A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.
| Original language | English |
|---|---|
| Pages (from-to) | 1782-1785 |
| Number of pages | 4 |
| Journal | Clinical Infectious Diseases |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 15 2001 |
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ASJC Scopus subject areas
- Immunology
Cite this
Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy : A case report. / Monini, P.; Sirianni, M. C.; Franco, M.; Vincenzi, L.; Topino, S.; Goletti, D.; Leone, P.; Leone, P.; Chiozzini, C.; Nicastri, E.; Andreoni, M.; Borduagni, O.; Sgadari, C.; Rezza, G.; Stürzl, M.; Ensoli, B.
In: Clinical Infectious Diseases, Vol. 33, No. 10, 15.11.2001, p. 1782-1785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy
T2 - A case report
AU - Monini, P.
AU - Sirianni, M. C.
AU - Franco, M.
AU - Vincenzi, L.
AU - Topino, S.
AU - Goletti, D.
AU - Leone, P.
AU - Leone, P.
AU - Chiozzini, C.
AU - Nicastri, E.
AU - Andreoni, M.
AU - Borduagni, O.
AU - Sgadari, C.
AU - Rezza, G.
AU - Stürzl, M.
AU - Ensoli, B.
PY - 2001/11/15
Y1 - 2001/11/15
N2 - A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.
AB - A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.
UR - http://www.scopus.com/inward/record.url?scp=0035889457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035889457&partnerID=8YFLogxK
U2 - 10.1086/323982
DO - 10.1086/323982
M3 - Article
VL - 33
SP - 1782
EP - 1785
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 10
ER -