Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report

P. Monini, M. C. Sirianni, M. Franco, L. Vincenzi, S. Topino, D. Goletti, P. Leone, P. Leone, C. Chiozzini, E. Nicastri, M. Andreoni, O. Borduagni, C. Sgadari, G. Rezza, M. Stürzl, B. Ensoli

Research output: Contribution to journalArticle

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Abstract

A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.

Original languageEnglish
Pages (from-to)1782-1785
Number of pages4
JournalClinical Infectious Diseases
Volume33
Issue number10
DOIs
Publication statusPublished - Nov 15 2001

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Human Herpesvirus 8
Kaposi's Sarcoma
Leukopenia
Interferons
Herpesviridae Infections
Therapeutics
Cell Count
HIV
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy : A case report. / Monini, P.; Sirianni, M. C.; Franco, M.; Vincenzi, L.; Topino, S.; Goletti, D.; Leone, P.; Leone, P.; Chiozzini, C.; Nicastri, E.; Andreoni, M.; Borduagni, O.; Sgadari, C.; Rezza, G.; Stürzl, M.; Ensoli, B.

In: Clinical Infectious Diseases, Vol. 33, No. 10, 15.11.2001, p. 1782-1785.

Research output: Contribution to journalArticle

Monini, P, Sirianni, MC, Franco, M, Vincenzi, L, Topino, S, Goletti, D, Leone, P, Leone, P, Chiozzini, C, Nicastri, E, Andreoni, M, Borduagni, O, Sgadari, C, Rezza, G, Stürzl, M & Ensoli, B 2001, 'Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report', Clinical Infectious Diseases, vol. 33, no. 10, pp. 1782-1785. https://doi.org/10.1086/323982
Monini, P. ; Sirianni, M. C. ; Franco, M. ; Vincenzi, L. ; Topino, S. ; Goletti, D. ; Leone, P. ; Leone, P. ; Chiozzini, C. ; Nicastri, E. ; Andreoni, M. ; Borduagni, O. ; Sgadari, C. ; Rezza, G. ; Stürzl, M. ; Ensoli, B. / Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy : A case report. In: Clinical Infectious Diseases. 2001 ; Vol. 33, No. 10. pp. 1782-1785.
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