Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-α therapy: A case report

P. Monini, M. C. Sirianni, M. Franco, L. Vincenzi, S. Topino, D. Goletti, P. Leone, P. Leone, C. Chiozzini, E. Nicastri, M. Andreoni, O. Borduagni, C. Sgadari, G. Rezza, M. Stürzl, B. Ensoli

Research output: Contribution to journalArticlepeer-review

Abstract

A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.

Original languageEnglish
Pages (from-to)1782-1785
Number of pages4
JournalClinical Infectious Diseases
Volume33
Issue number10
DOIs
Publication statusPublished - Nov 15 2001

ASJC Scopus subject areas

  • Immunology

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