TY - JOUR
T1 - Click-evoked otoacoustic emissions recorded from untreated congenital hypothyroid newborns
AU - Parazzini, Marta
AU - Ravazzani, Paolo
AU - Medaglini, Stefania
AU - Weber, Giovanna
AU - Fornara, Carla
AU - Tognola, Gabriella
AU - Vigone, Maria Cristina
AU - Bianchi, Carlo
AU - Comi, Giancarlo
AU - Chiumello, Giuseppe
AU - Grandori, Ferdinando
PY - 2002
Y1 - 2002
N2 - Thyroid hormone plays an important role in hearing development. Both a genetic or non-genetic hypothyroidism is often associated with congenital hearing loss. The exact incidence of hearing impairment in untreated congenital hypothyroid (CH) patients is unknown. This paper will present the results of measuring of the transient-evoked otoacoustic emissions (TEOAE) in a population of 29 newborns, who tested positive on a screening test for hypothyroidism (CH group) and in 68 well babies (control group) randomly chosen from all the newborns, classified as PASS, included in the Hearing Screening Program of the San Raffaele Hospital in Milan. TEOAE were recorded in all newborns within 1 month after birth and before beginning L-thyroxine treatment with conventional commercial instrumentation. Both temporal and time-frequency analyses of the emitted responses were conducted by means of a wavelet transform. The comparison of the characteristics of the temporal and frequency content of the responses of the two groups (CH and control) showed no statistically significant difference. No correlation was found between outer hair cell dysfunction and hypothyroidism.
AB - Thyroid hormone plays an important role in hearing development. Both a genetic or non-genetic hypothyroidism is often associated with congenital hearing loss. The exact incidence of hearing impairment in untreated congenital hypothyroid (CH) patients is unknown. This paper will present the results of measuring of the transient-evoked otoacoustic emissions (TEOAE) in a population of 29 newborns, who tested positive on a screening test for hypothyroidism (CH group) and in 68 well babies (control group) randomly chosen from all the newborns, classified as PASS, included in the Hearing Screening Program of the San Raffaele Hospital in Milan. TEOAE were recorded in all newborns within 1 month after birth and before beginning L-thyroxine treatment with conventional commercial instrumentation. Both temporal and time-frequency analyses of the emitted responses were conducted by means of a wavelet transform. The comparison of the characteristics of the temporal and frequency content of the responses of the two groups (CH and control) showed no statistically significant difference. No correlation was found between outer hair cell dysfunction and hypothyroidism.
KW - Hypothyroidism
KW - Newborn
KW - Transient-evoked otoacoustic emission
KW - Wavelet transform
UR - http://www.scopus.com/inward/record.url?scp=0035985778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035985778&partnerID=8YFLogxK
U2 - 10.1016/S0378-5955(02)00307-6
DO - 10.1016/S0378-5955(02)00307-6
M3 - Article
C2 - 12062765
AN - SCOPUS:0035985778
VL - 166
SP - 136
EP - 142
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -