Clinical aggressiveness and long-term outcome in patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies

Cosimo Durante, Sara Tognini, Teresa Montesano, Fabio Orlandi, Massimo Torlontano, Efisio Puxeddu, Marco Attard, Giuseppe Costante, Salvatore Tumino, Domenico Meringolo, Rocco Bruno, Fabiana Trulli, Maria Toteda, Adriano Redler, Giuseppe Ronga, Sebastiano Filetti, Fabio Monzani

Research output: Contribution to journalArticle

Abstract

Objective: The association between papillary thyroid cancer (PTC) and Hashimoto's thyroiditis is widely recognized, but less is known about the possible link between circulating anti-thyroglobulin antibody (TgAb) titers and PTC aggressiveness. To shed light on this issue, we retrospectively examined a large series of PTC patients with and without positive TgAb. Methods: Data on 220 TgAb-positive PTC patients (study cohort) were retrospectively collected in 10 hospital-based referral centers. All the patients had undergone near-total thyroidectomy with or without radioiodine remnant ablation. Tumor characteristics and long-term outcomes (follow-up range: 2.5-24.8 years) were compared with those recently reported in 1020 TgAb-negative PTC patients with similar demographic characteristics. We also assessed the impact on clinical outcome of early titer disappearance in the TgAb-positive group. Results: At baseline, the study cohort (mean age 45.9 years, range 12.5-84.1 years; 85% female) had a significantly higher prevalence of high-risk patients (6.9% vs. 3.2%, p

Original languageEnglish
Pages (from-to)1139-1145
Number of pages7
JournalThyroid
Volume24
Issue number7
DOIs
Publication statusPublished - Jul 1 2014

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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    Durante, C., Tognini, S., Montesano, T., Orlandi, F., Torlontano, M., Puxeddu, E., Attard, M., Costante, G., Tumino, S., Meringolo, D., Bruno, R., Trulli, F., Toteda, M., Redler, A., Ronga, G., Filetti, S., & Monzani, F. (2014). Clinical aggressiveness and long-term outcome in patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies. Thyroid, 24(7), 1139-1145. https://doi.org/10.1089/thy.2013.0698