Clinical analysis of macular edema with new software for SD-OCT imaging

Claudio Azzolini, Giovanna Sansoni, Simone Donati, Maurizio Battaglia Parodi, Muna Al Oum, Riccardo Vinciguerra, Valerio Tartaglia, Francesco Semeraro, Gianni Virgili

Research output: Contribution to journalArticlepeer-review


To evaluate the clinical efficacy of user-friendly software for the measurement of intraretinal hyporeflective spaces expression of macular edema. Methods: Fifteen consecutive patients with diabetic retinopathy with clinically significant macular edema were examined using conventional spectral domain optical coherence tomography (OCT). A new composite software application, OCT-measurement analysis tool (OCT-MAT), was developed to automatically process and analyze OCT B-scans by means of image acquisition, filtering, and elaboration, together with hyporeflective area recognition and measurement in μm2. The same macular areas were measured manually, and then compared to the measurements obtained by the automated OCT-MAT software. A statistical t test analysis was applied (statistical significance level at p2. The comparison between mean manual measurements and OCT-MAT measurements (0.478 ± 0.300 × 106 μm2 vs 0.471 ± 0.321 × 106 μm2) showed correct correspondence (p>0.05). Moreover, the OCT-MAT software showed good repeatability and reproducibility (coefficient below 3%). conclusions: OCT-MAT allows the precise measurement of macular edema in terms of the number of empty spaces and their size in all patients. Its daily clinical application might give precise information regarding the evolution of macular edema and the efficacy of therapy.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalEuropean Journal of Ophthalmology
Issue number6
Publication statusPublished - Jun 23 2013


  • Macular edema
  • Measurement software
  • Optical coherence tomography
  • Retinal imaging

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)


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