Clinical and angiographic outcome after sirolimus-eluting stent implantation in aorto-ostial lesions

Ioannis Iakovou, Lei Ge, Iassen Michev, Giuseppe M. Sangiorgi, Matteo Montorfano, Flavio Airoldi, Alaide Chieffo, Goran Stankovic, Giancarlo Vitrella, Mauro Carlino, Nicola Corvaja, Carlo Briguori, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


This observational study evaluated the clinical and angiographic outcomes of patients with aorto-ostial coronary artery disease treated with sirolimus-eluting stents (SESs) or with bare metal stents (BMSs). The safety and effectiveness of SESs for the treatment of aorto-ostial lesions have not been demonstrated. We identified 82 consecutive patients who underwent percutaneous coronary interventions in 82 aorto-ostial lesions using the SES (32 patients) or BMS (50 patients) and compared the two groups of patients. The incidence of major adverse cardiac events (MACE), including death or Q-wave myocardial infarction (MI), target lesion revascularization (TLR), and target vessel revascularization (TVR), were recorded in-hospital and at a 10-month follow-up. All stents were implanted successfully. There were no statisticallysignificant differences regarding major in-hospital complications between the two groups. At 10-month follow-up, two (6.3%) patients in the SES group and 14 (28%) patients in the BMS group underwent TLR (p = 0.01); MACE were less frequent in the SES group compared to the BMS group (19% vs. 44%, p = 0.02). Angiographic follow-up showed lower binary restenosis rates (11% vs. 51%, p = 0.001) and smaller late loss (0.21 ± 0.31 mm vs. 2.06 ± 1.37 mm, p <0.0001) in the SES group. The main finding of our study is that, compared to the BMS, implantation of the SES in aorto-ostial lesions appears safe and effective, with no increase in major in-hospital complications and a significant improvement in restenosis and late event rates at 10-month follow-up.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalJournal of the American College of Cardiology
Issue number5
Publication statusPublished - Sep 1 2004

ASJC Scopus subject areas

  • Nursing(all)


Dive into the research topics of 'Clinical and angiographic outcome after sirolimus-eluting stent implantation in aorto-ostial lesions'. Together they form a unique fingerprint.

Cite this