Clinical and angiographic outcome after sirolimus-eluting stent implantation in aorto-ostial lesions

Ioannis Iakovou, Lei Ge, Iassen Michev, Giuseppe M. Sangiorgi, Matteo Montorfano, Flavio Airoldi, Alaide Chieffo, Goran Stankovic, Giancarlo Vitrella, Mauro Carlino, Nicola Corvaja, Carlo Briguori, Antonio Colombo

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Abstract

This observational study evaluated the clinical and angiographic outcomes of patients with aorto-ostial coronary artery disease treated with sirolimus-eluting stents (SESs) or with bare metal stents (BMSs). The safety and effectiveness of SESs for the treatment of aorto-ostial lesions have not been demonstrated. We identified 82 consecutive patients who underwent percutaneous coronary interventions in 82 aorto-ostial lesions using the SES (32 patients) or BMS (50 patients) and compared the two groups of patients. The incidence of major adverse cardiac events (MACE), including death or Q-wave myocardial infarction (MI), target lesion revascularization (TLR), and target vessel revascularization (TVR), were recorded in-hospital and at a 10-month follow-up. All stents were implanted successfully. There were no statisticallysignificant differences regarding major in-hospital complications between the two groups. At 10-month follow-up, two (6.3%) patients in the SES group and 14 (28%) patients in the BMS group underwent TLR (p = 0.01); MACE were less frequent in the SES group compared to the BMS group (19% vs. 44%, p = 0.02). Angiographic follow-up showed lower binary restenosis rates (11% vs. 51%, p = 0.001) and smaller late loss (0.21 ± 0.31 mm vs. 2.06 ± 1.37 mm, p <0.0001) in the SES group. The main finding of our study is that, compared to the BMS, implantation of the SES in aorto-ostial lesions appears safe and effective, with no increase in major in-hospital complications and a significant improvement in restenosis and late event rates at 10-month follow-up.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalJournal of the American College of Cardiology
Volume44
Issue number5
DOIs
Publication statusPublished - Sep 1 2004

ASJC Scopus subject areas

  • Nursing(all)

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