Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Ql0

N. Bresolin, L. Bet, A. Binda, M. Moggio, G. Comi, F. Nador, C. Ferrante, A. Carenzi, G. Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most of our patients showed a progressive reduction of serum lactate and pyruvate levels following standard muscle exercise and generally improved neurologic functions. The ECG and echocardiogram showed no significant changes in our patients. None of our patients showed any improvement in ptosis and CPEO.

Original languageEnglish
Pages (from-to)892-899
Number of pages8
JournalNeurology
Volume38
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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