Clinical and biological features of an intranodal palisaded myofibroblastoma

Umile Michele Cosenza, G. Galati, P. Zofrea, S. Maggi, A. Marasco, M. Castelli, L. Masoni, A. Brescia

Research output: Contribution to journalArticlepeer-review

Abstract

Intranodal palisaded myofibroblastoma (IPM) is a rare benign tumor of the lymph nodes probably arising from smooth muscle-like cells. The tumor is characterized by intranodal proliferation of spindle cells. Neoplastic spindle-cell proliferation is most often of metastatic repetition which is very important in the recognition of IPM, because it may be mistaken for metastasis or other tumors such as Kaposi's sarcoma. We report a novel case of IPM that confirms the myofibroblastic differentiation of the tumor. The onset of IPM has been associated with Epstein-Barr virus (EBV). In addition, recently reported cases of IPM have been seen with cyclin 1 overexpression and also with human herpes virus (HHV)-8 and EBVDNA sequences. In our case, there was no evidence of HHV-8 and EBVDNA sequences and we were not able to find cyclin 1 overexpression.

Original languageEnglish
Pages (from-to)2349-2352
Number of pages4
JournalAnticancer Research
Volume26
Issue number3 B
Publication statusPublished - May 2006

Keywords

  • Mesenchymal neoplasm
  • Myofibroblast
  • Myofibroblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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