Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study

Research output: Contribution to journalArticle

Abstract

The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined. We performed a cross-sectional study correlating local and systemic biological characteristics with the patients' characteristics. We evaluated both local tissue markers (CD34, CD146, CD166, and tartrate-resistant acid phosphatase (TRAP)) and systemic serum biomarkers (fragments or propeptide of type II collagen: C2C, CTX-II, CPII, and TRAP5b) on histologically scored osteochondral fragments or serum from OCD patients. These biological features were associated with the patients' characteristics (IKDC subjective score, age, and body mass index (BMI)). Histological cartilage tissue score correlated with patients' IKDC and C2C and CPII biomarkers. CPII correlated also with histological bone tissue score. The percentage of CD146 positive cells in cartilage and CD34 positive cells in bone highly correlated with the patient's age and BMI, respectively. The percentage of TRAP in bone was directly correlated with both IKDC and age. Multivariate statistical analysis evidenced that only four parameters significantly predicted IKDC. In conclusion, a complete picture of OCD knee characteristics, defined by local and systemic markers of cartilage and bone remodeling, together with the patients' characteristics, might help to better understand the healing potential of each patient and to target and improve current OCD treatments.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBioMed Research International
Volume2018
DOIs
Publication statusPublished - May 2018

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Osteochondritis Dissecans
Bone
Cartilage
Cross-Sectional Studies
Biomarkers
Tissue
Acid Phosphatase
Cells
Collagen Type II
Bone and Bones
Knee
Body Mass Index
Statistical methods
Bone Remodeling
Serum
Multivariate Analysis
tartaric acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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title = "Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study",
abstract = "The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined. We performed a cross-sectional study correlating local and systemic biological characteristics with the patients' characteristics. We evaluated both local tissue markers (CD34, CD146, CD166, and tartrate-resistant acid phosphatase (TRAP)) and systemic serum biomarkers (fragments or propeptide of type II collagen: C2C, CTX-II, CPII, and TRAP5b) on histologically scored osteochondral fragments or serum from OCD patients. These biological features were associated with the patients' characteristics (IKDC subjective score, age, and body mass index (BMI)). Histological cartilage tissue score correlated with patients' IKDC and C2C and CPII biomarkers. CPII correlated also with histological bone tissue score. The percentage of CD146 positive cells in cartilage and CD34 positive cells in bone highly correlated with the patient's age and BMI, respectively. The percentage of TRAP in bone was directly correlated with both IKDC and age. Multivariate statistical analysis evidenced that only four parameters significantly predicted IKDC. In conclusion, a complete picture of OCD knee characteristics, defined by local and systemic markers of cartilage and bone remodeling, together with the patients' characteristics, might help to better understand the healing potential of each patient and to target and improve current OCD treatments.",
author = "Elena Gabusi and Cristina Manferdini and Francesca Paolella and Laura Gambari and Elizaveta Kon and Giuseppe Filardo and Erminia Mariani and Gina Lisignoli",
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AU - Gabusi, Elena

AU - Manferdini, Cristina

AU - Paolella, Francesca

AU - Gambari, Laura

AU - Kon, Elizaveta

AU - Filardo, Giuseppe

AU - Mariani, Erminia

AU - Lisignoli, Gina

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