Clinical and cardiorespiratory assessment in children with down syndrome without congenital heart disease

Enrica Pastore, Bruno Marino, Armando Calzolari, Maria Cristina Digilio, Aldo Giannotti, Attilio Turchetta

Research output: Contribution to journalArticlepeer-review


Objective: To assess the clinical and functional status of a young Down syndrome (DS) population without congenital heart disease. Design: Prospective study of children with DS and control subjects. Setting: Bambino Gesu Children's Hospital, Rome, Italy. Participants and Methods: Forty-two children with DS (mean ± SD age, 9.8 ± 3.6 years) underwent genetic, clinical, neuropsychological (IQ), and cardiorespiratory evaluation. Cardiorespiratory fitness was assessed with a treadmill test and a lung function test to determine forced vital capacity, first-second forced expiratory volume, and peak expiratory flow. Data were expressed as a percentage of the predicted values for control children. To assess cooperation during exercise testing, we devised a compliance scale assigning a score according to the subjects' ability to understand instructions, ability to walk and run as required, and need for vocal encouragement. Results: Eighteen (43%) of 42 children with DS were obese, 10 (24%) were short, and 17 (40%) had microcephaly. On the Leiter International Performance Scale, 2 of 35 subjects had a normal IQ score (80-120); all others had low IQ scores (79 to

Original languageEnglish
Pages (from-to)408-410
Number of pages3
JournalArchives of Pediatrics and Adolescent Medicine
Issue number4
Publication statusPublished - Apr 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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