Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas

Iris Zalaudek, Claudio Conforti, Fabrizio Guarneri, Roberta Vezzoni, Teresa Deinlein, Rainer Hofmann-Wellenhof, Caterina Longo, Elvira Moscarella, Harald Kittler, Giuseppe Argenziano, Roberta Giuffrida

Research output: Contribution to journalArticlepeer-review


Background: No specific features of nevus-associated melanoma (NAM) are currently defined. Objective: To identify clinical/dermoscopic features of NAM. Methods: Retrospective evaluation of histopathologically diagnosed NAM. Results: Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Limitations: Retrospective analysis. Conclusion: C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients.

Original languageEnglish
Pages (from-to)1080-1087
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number4
Publication statusPublished - Oct 2020


  • dermoscopy
  • melanoma
  • nevogenesis
  • nevus
  • nevus-associated melanoma
  • skin cancer

ASJC Scopus subject areas

  • Dermatology


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