TY - JOUR
T1 - Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas
AU - Zalaudek, Iris
AU - Conforti, Claudio
AU - Guarneri, Fabrizio
AU - Vezzoni, Roberta
AU - Deinlein, Teresa
AU - Hofmann-Wellenhof, Rainer
AU - Longo, Caterina
AU - Moscarella, Elvira
AU - Kittler, Harald
AU - Argenziano, Giuseppe
AU - Giuffrida, Roberta
N1 - Funding Information:
Funding sources: None.
Publisher Copyright:
© 2020 American Academy of Dermatology, Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Background: No specific features of nevus-associated melanoma (NAM) are currently defined. Objective: To identify clinical/dermoscopic features of NAM. Methods: Retrospective evaluation of histopathologically diagnosed NAM. Results: Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Limitations: Retrospective analysis. Conclusion: C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients.
AB - Background: No specific features of nevus-associated melanoma (NAM) are currently defined. Objective: To identify clinical/dermoscopic features of NAM. Methods: Retrospective evaluation of histopathologically diagnosed NAM. Results: Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Limitations: Retrospective analysis. Conclusion: C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients.
KW - dermoscopy
KW - melanoma
KW - nevogenesis
KW - nevus
KW - nevus-associated melanoma
KW - skin cancer
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U2 - 10.1016/j.jaad.2020.04.120
DO - 10.1016/j.jaad.2020.04.120
M3 - Article
C2 - 32360715
AN - SCOPUS:85089400154
VL - 83
SP - 1080
EP - 1087
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 4
ER -