Clinical and dermoscopic characterization of pediatric and adolescent melanomas: Multicenter study of 52 cases

Cristina Carrera, Alon Scope, Stephen W. Dusza, Giuseppe Argenziano, Gianluca Nazzaro, Alice Phan, Isabelle Tromme, Pietro Rubegni, Josep Malvehy, Susana Puig, Ashfaq A. Marghoob

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse, and this may in part contribute to delay in detection and thicker tumors. Objective: To analyze the clinicodermoscopic characteristics of PM. Methods: Retrospective study of 52 melanomas diagnosed in patients before the age of 20 years. Results: On the basis of its clinical, dermoscopic, and histopathologic characteristics, PM can be classified as spitzoid or nonspitzoid. The nonspitzoid melanomas (n = 37 [72.3%]) presented in patients with a mean age of 16.3 years (range, 8-20) and were associated with a high-risk phenotype and a pre-existing nevus (62.2%). The spitzoid melanomas (n = 15 [27.7%]) were diagnosed in patients at a mean age of 12.5 years (range, 2-19) and were mostly de novo lesions (73.3%) located on the limbs (73.3%). Whereas less than 25% of PMs fulfilled the modified clinical ABCD criteria (amelanotic, bleeding bump, uniformity color, de novo at any diameter), 40% of spitzoid melanomas did. Dermoscopic melanoma criteria were found in all cases. Nonspitzoid melanomas tended to be multicomponent (58.3%) or have nevus-like (25%) dermoscopic patterns. Spitzoid melanomas revealed atypical vascular patterns with shiny white lines (46.2%) or an atypical pigmented spitzoid pattern (30.8%). There was good correlation between spitzoid subtype histopathologically and dermoscopically (κ = 0.66). Limitations: A retrospective study without re-review of pathologic findings. Conclusion: Dermoscopy in addition to conventional and modified clinical ABCD criteria helps in detecting PM. Dermoscopy assists in differentiating spitzoid from nonspitzoid melanomas.

Original languageEnglish
Pages (from-to)278-288
JournalJournal of the American Academy of Dermatology
Volume78
Issue number2
DOIs
Publication statusPublished - 2018

Fingerprint

Multicenter Studies
Melanoma
Pediatrics
Dermoscopy
Nevus
Retrospective Studies
Blood Vessels
Extremities
Color
Hemorrhage
Phenotype

Keywords

  • Childhood
  • Dermoscopy
  • Detection
  • Melanoma
  • Pediatric melanoma
  • Spitz
  • Spitzoid

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical and dermoscopic characterization of pediatric and adolescent melanomas : Multicenter study of 52 cases. / Carrera, Cristina; Scope, Alon; Dusza, Stephen W.; Argenziano, Giuseppe; Nazzaro, Gianluca; Phan, Alice; Tromme, Isabelle; Rubegni, Pietro; Malvehy, Josep; Puig, Susana; Marghoob, Ashfaq A.

In: Journal of the American Academy of Dermatology, Vol. 78, No. 2, 2018, p. 278-288.

Research output: Contribution to journalArticle

Carrera, C, Scope, A, Dusza, SW, Argenziano, G, Nazzaro, G, Phan, A, Tromme, I, Rubegni, P, Malvehy, J, Puig, S & Marghoob, AA 2018, 'Clinical and dermoscopic characterization of pediatric and adolescent melanomas: Multicenter study of 52 cases', Journal of the American Academy of Dermatology, vol. 78, no. 2, pp. 278-288. https://doi.org/10.1016/j.jaad.2017.09.065
Carrera, Cristina ; Scope, Alon ; Dusza, Stephen W. ; Argenziano, Giuseppe ; Nazzaro, Gianluca ; Phan, Alice ; Tromme, Isabelle ; Rubegni, Pietro ; Malvehy, Josep ; Puig, Susana ; Marghoob, Ashfaq A. / Clinical and dermoscopic characterization of pediatric and adolescent melanomas : Multicenter study of 52 cases. In: Journal of the American Academy of Dermatology. 2018 ; Vol. 78, No. 2. pp. 278-288.
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abstract = "Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse, and this may in part contribute to delay in detection and thicker tumors. Objective: To analyze the clinicodermoscopic characteristics of PM. Methods: Retrospective study of 52 melanomas diagnosed in patients before the age of 20 years. Results: On the basis of its clinical, dermoscopic, and histopathologic characteristics, PM can be classified as spitzoid or nonspitzoid. The nonspitzoid melanomas (n = 37 [72.3{\%}]) presented in patients with a mean age of 16.3 years (range, 8-20) and were associated with a high-risk phenotype and a pre-existing nevus (62.2{\%}). The spitzoid melanomas (n = 15 [27.7{\%}]) were diagnosed in patients at a mean age of 12.5 years (range, 2-19) and were mostly de novo lesions (73.3{\%}) located on the limbs (73.3{\%}). Whereas less than 25{\%} of PMs fulfilled the modified clinical ABCD criteria (amelanotic, bleeding bump, uniformity color, de novo at any diameter), 40{\%} of spitzoid melanomas did. Dermoscopic melanoma criteria were found in all cases. Nonspitzoid melanomas tended to be multicomponent (58.3{\%}) or have nevus-like (25{\%}) dermoscopic patterns. Spitzoid melanomas revealed atypical vascular patterns with shiny white lines (46.2{\%}) or an atypical pigmented spitzoid pattern (30.8{\%}). There was good correlation between spitzoid subtype histopathologically and dermoscopically (κ = 0.66). Limitations: A retrospective study without re-review of pathologic findings. Conclusion: Dermoscopy in addition to conventional and modified clinical ABCD criteria helps in detecting PM. Dermoscopy assists in differentiating spitzoid from nonspitzoid melanomas.",
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AU - Carrera, Cristina

AU - Scope, Alon

AU - Dusza, Stephen W.

AU - Argenziano, Giuseppe

AU - Nazzaro, Gianluca

AU - Phan, Alice

AU - Tromme, Isabelle

AU - Rubegni, Pietro

AU - Malvehy, Josep

AU - Puig, Susana

AU - Marghoob, Ashfaq A.

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N2 - Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse, and this may in part contribute to delay in detection and thicker tumors. Objective: To analyze the clinicodermoscopic characteristics of PM. Methods: Retrospective study of 52 melanomas diagnosed in patients before the age of 20 years. Results: On the basis of its clinical, dermoscopic, and histopathologic characteristics, PM can be classified as spitzoid or nonspitzoid. The nonspitzoid melanomas (n = 37 [72.3%]) presented in patients with a mean age of 16.3 years (range, 8-20) and were associated with a high-risk phenotype and a pre-existing nevus (62.2%). The spitzoid melanomas (n = 15 [27.7%]) were diagnosed in patients at a mean age of 12.5 years (range, 2-19) and were mostly de novo lesions (73.3%) located on the limbs (73.3%). Whereas less than 25% of PMs fulfilled the modified clinical ABCD criteria (amelanotic, bleeding bump, uniformity color, de novo at any diameter), 40% of spitzoid melanomas did. Dermoscopic melanoma criteria were found in all cases. Nonspitzoid melanomas tended to be multicomponent (58.3%) or have nevus-like (25%) dermoscopic patterns. Spitzoid melanomas revealed atypical vascular patterns with shiny white lines (46.2%) or an atypical pigmented spitzoid pattern (30.8%). There was good correlation between spitzoid subtype histopathologically and dermoscopically (κ = 0.66). Limitations: A retrospective study without re-review of pathologic findings. Conclusion: Dermoscopy in addition to conventional and modified clinical ABCD criteria helps in detecting PM. Dermoscopy assists in differentiating spitzoid from nonspitzoid melanomas.

AB - Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse, and this may in part contribute to delay in detection and thicker tumors. Objective: To analyze the clinicodermoscopic characteristics of PM. Methods: Retrospective study of 52 melanomas diagnosed in patients before the age of 20 years. Results: On the basis of its clinical, dermoscopic, and histopathologic characteristics, PM can be classified as spitzoid or nonspitzoid. The nonspitzoid melanomas (n = 37 [72.3%]) presented in patients with a mean age of 16.3 years (range, 8-20) and were associated with a high-risk phenotype and a pre-existing nevus (62.2%). The spitzoid melanomas (n = 15 [27.7%]) were diagnosed in patients at a mean age of 12.5 years (range, 2-19) and were mostly de novo lesions (73.3%) located on the limbs (73.3%). Whereas less than 25% of PMs fulfilled the modified clinical ABCD criteria (amelanotic, bleeding bump, uniformity color, de novo at any diameter), 40% of spitzoid melanomas did. Dermoscopic melanoma criteria were found in all cases. Nonspitzoid melanomas tended to be multicomponent (58.3%) or have nevus-like (25%) dermoscopic patterns. Spitzoid melanomas revealed atypical vascular patterns with shiny white lines (46.2%) or an atypical pigmented spitzoid pattern (30.8%). There was good correlation between spitzoid subtype histopathologically and dermoscopically (κ = 0.66). Limitations: A retrospective study without re-review of pathologic findings. Conclusion: Dermoscopy in addition to conventional and modified clinical ABCD criteria helps in detecting PM. Dermoscopy assists in differentiating spitzoid from nonspitzoid melanomas.

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