Clinical and electrocardiographic features and long-term results of electrical therapy in patients with isolated His bundle disease

Lucia M. Mangiardi, Giuliana Ronzani, Fiorenzo Gaita, Patrizia Presbitero, Maria Rosa Conte, Margherita Di Leo, Enzo Commodo, Antonio Brusca

Research output: Contribution to journalArticle

Abstract

The clinical, ECG, and electrophysiologic findings of 35 consecutive patients with second- and third-degree intra-His block with normal QRS complexes were examined. The follow-up period varied between 12 and 120 months (mean 45). Seventy-seven per cent of the patients were women. Underlying heart disease was present in 43% of the patients. ECGs were characterized by both second-degree type I and type II atrioventricular block, normal or slightly prolonged PR interval of the conducted beats or of the first conducted beat of a Wenckebach sequence, and by subtle changes in the initial forces of the QRS complexes of the escape beats. Electrophysiologic study showed normal sinus and atrioventricular node function and normal infra-His conduction in all patients. In four patients repetitive bradycardia-dependent intra-His block was induced. Thirty-two patients were permanently paced soon after the initial evaluation and three during the follow-up period. Total long-term mortality rate was 23%. None of the patients developed bundle branch block.

Original languageEnglish
Pages (from-to)1183-1191
Number of pages9
JournalAmerican Heart Journal
Volume112
Issue number6
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Mangiardi, L. M., Ronzani, G., Gaita, F., Presbitero, P., Conte, M. R., Di Leo, M., Commodo, E., & Brusca, A. (1986). Clinical and electrocardiographic features and long-term results of electrical therapy in patients with isolated His bundle disease. American Heart Journal, 112(6), 1183-1191. https://doi.org/10.1016/0002-8703(86)90347-9