Clinical and genetic aspects of phaeochromocytoma

Giuseppe Opocher, Francesca Schiavi, Pierantonio Conton, Carla Scaroni, Franco Mantero

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Phaeochromocytoma is a tumour of the adrenal medulla, which, although rare, is a major cause of correctable hypertension with a prevalence of 0.1-0.5% in the hypertensive population. Clinical symptoms include attacks of paroxysmal headache, sweating, palpitations, stress and a sense of imminent death. Often associated with the above is an increase in blood pressure. Despite the fact that the underlying genetic mechanisms of phaeochromocytoma have been well investigated, they are still incompletely understood. In approximately 80% of cases the tumour occurs sporadically, but it may occur in association with type 2 multiple endocrine neoplasia, type 1 neurofibromatosis or von Hippel-Lindau disease. Molecular evidence suggests that other genes such as SDHD or SDHB may control its development; the possibility of other putative phaeochromocytoma genes is currently being investigated.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalHormone Research
Volume59
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2003

Fingerprint

Pheochromocytoma
von Hippel-Lindau Disease
Multiple Endocrine Neoplasia Type 1
Neurofibromatosis 1
Adrenal Medulla
Sweating
Genes
Headache
Neoplasms
Blood Pressure
Hypertension
Population

Keywords

  • Chromosome 1
  • Genetics
  • Phaeochromocytoma

ASJC Scopus subject areas

  • Endocrinology

Cite this

Opocher, G., Schiavi, F., Conton, P., Scaroni, C., & Mantero, F. (2003). Clinical and genetic aspects of phaeochromocytoma. Hormone Research, 59(SUPPL. 1), 56-61. https://doi.org/10.1159/000067846

Clinical and genetic aspects of phaeochromocytoma. / Opocher, Giuseppe; Schiavi, Francesca; Conton, Pierantonio; Scaroni, Carla; Mantero, Franco.

In: Hormone Research, Vol. 59, No. SUPPL. 1, 2003, p. 56-61.

Research output: Contribution to journalArticle

Opocher, G, Schiavi, F, Conton, P, Scaroni, C & Mantero, F 2003, 'Clinical and genetic aspects of phaeochromocytoma', Hormone Research, vol. 59, no. SUPPL. 1, pp. 56-61. https://doi.org/10.1159/000067846
Opocher G, Schiavi F, Conton P, Scaroni C, Mantero F. Clinical and genetic aspects of phaeochromocytoma. Hormone Research. 2003;59(SUPPL. 1):56-61. https://doi.org/10.1159/000067846
Opocher, Giuseppe ; Schiavi, Francesca ; Conton, Pierantonio ; Scaroni, Carla ; Mantero, Franco. / Clinical and genetic aspects of phaeochromocytoma. In: Hormone Research. 2003 ; Vol. 59, No. SUPPL. 1. pp. 56-61.
@article{e70578e8af044dbe92943c0dc50a2a12,
title = "Clinical and genetic aspects of phaeochromocytoma",
abstract = "Phaeochromocytoma is a tumour of the adrenal medulla, which, although rare, is a major cause of correctable hypertension with a prevalence of 0.1-0.5{\%} in the hypertensive population. Clinical symptoms include attacks of paroxysmal headache, sweating, palpitations, stress and a sense of imminent death. Often associated with the above is an increase in blood pressure. Despite the fact that the underlying genetic mechanisms of phaeochromocytoma have been well investigated, they are still incompletely understood. In approximately 80{\%} of cases the tumour occurs sporadically, but it may occur in association with type 2 multiple endocrine neoplasia, type 1 neurofibromatosis or von Hippel-Lindau disease. Molecular evidence suggests that other genes such as SDHD or SDHB may control its development; the possibility of other putative phaeochromocytoma genes is currently being investigated.",
keywords = "Chromosome 1, Genetics, Phaeochromocytoma",
author = "Giuseppe Opocher and Francesca Schiavi and Pierantonio Conton and Carla Scaroni and Franco Mantero",
year = "2003",
doi = "10.1159/000067846",
language = "English",
volume = "59",
pages = "56--61",
journal = "Hormone Research",
issn = "0301-0163",
publisher = "S. Karger AG",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Clinical and genetic aspects of phaeochromocytoma

AU - Opocher, Giuseppe

AU - Schiavi, Francesca

AU - Conton, Pierantonio

AU - Scaroni, Carla

AU - Mantero, Franco

PY - 2003

Y1 - 2003

N2 - Phaeochromocytoma is a tumour of the adrenal medulla, which, although rare, is a major cause of correctable hypertension with a prevalence of 0.1-0.5% in the hypertensive population. Clinical symptoms include attacks of paroxysmal headache, sweating, palpitations, stress and a sense of imminent death. Often associated with the above is an increase in blood pressure. Despite the fact that the underlying genetic mechanisms of phaeochromocytoma have been well investigated, they are still incompletely understood. In approximately 80% of cases the tumour occurs sporadically, but it may occur in association with type 2 multiple endocrine neoplasia, type 1 neurofibromatosis or von Hippel-Lindau disease. Molecular evidence suggests that other genes such as SDHD or SDHB may control its development; the possibility of other putative phaeochromocytoma genes is currently being investigated.

AB - Phaeochromocytoma is a tumour of the adrenal medulla, which, although rare, is a major cause of correctable hypertension with a prevalence of 0.1-0.5% in the hypertensive population. Clinical symptoms include attacks of paroxysmal headache, sweating, palpitations, stress and a sense of imminent death. Often associated with the above is an increase in blood pressure. Despite the fact that the underlying genetic mechanisms of phaeochromocytoma have been well investigated, they are still incompletely understood. In approximately 80% of cases the tumour occurs sporadically, but it may occur in association with type 2 multiple endocrine neoplasia, type 1 neurofibromatosis or von Hippel-Lindau disease. Molecular evidence suggests that other genes such as SDHD or SDHB may control its development; the possibility of other putative phaeochromocytoma genes is currently being investigated.

KW - Chromosome 1

KW - Genetics

KW - Phaeochromocytoma

UR - http://www.scopus.com/inward/record.url?scp=0037262032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037262032&partnerID=8YFLogxK

U2 - 10.1159/000067846

DO - 10.1159/000067846

M3 - Article

C2 - 12566722

AN - SCOPUS:0037262032

VL - 59

SP - 56

EP - 61

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

IS - SUPPL. 1

ER -