Clinical and genetic characteristics of late-onset Huntington's disease

Mayke Oosterloo, Emilia K. Bijlsma, Sander MJ van Kuijk, Floor Minkels, Christine EM de Die-Smulders, for the REGISTRY Investigators of the European Huntington's Disease Network, Registry Steering committee, Anne Catherine Bachoud-Lévi, Anna Rita Bentivoglio, Raphael M. Bonelli, Ida Biunno, Juliana Bronzova, Jean Marc Burgunder, Stephen B. Dunnett, Joaquim J. Ferreira, Jan Frich, Joe Giuliano, Olivia J. Handley, Arvid Heiberg, Sergey IllarioshkinTorsten Illmann, Jiri Klempir, Paolo Milani, Claudia Cormio, Giovanna Calandra-Buonaura, Sabina Capellari, Pietro Cortelli, Roberto Poda, Language coordinators, Cesa Scaglione, Silvia Piacentini, Anna Maria Romoli, Sandro Sorbi, Alberto Albanese, Simona Castagliuolo, Anna Castaldo, Stefano Di Donato, Daniela Di Bella, Cinzia Gellera, Caterina Mariotti, Lorenzo Nanetti, Paola Soliveri, Franco Taroni, Giuseppe De Michele, Marco Massarelli, Cinzia Valeria Russo, Milena Cannella, Valentina Codella, Francesca Elifani, Martina Petrollini, Ferdinando Squitieri, Anna Rita Bentivoglio, Federica Esposito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients.

Original languageEnglish
JournalParkinsonism and Related Disorders
DOIs
Publication statusE-pub ahead of print - Nov 1 2018

Fingerprint

Huntington Disease
Gait
Disease Progression
Registries
Databases
Population

Keywords

  • Age of onset
  • Huntington's disease
  • Late-onset Huntington's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Oosterloo, M., Bijlsma, E. K., van Kuijk, S. MJ., Minkels, F., de Die-Smulders, C. EM., for the REGISTRY Investigators of the European Huntington's Disease Network, ... Esposito, F. (2018). Clinical and genetic characteristics of late-onset Huntington's disease. Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2018.11.009

Clinical and genetic characteristics of late-onset Huntington's disease. / Oosterloo, Mayke; Bijlsma, Emilia K.; van Kuijk, Sander MJ; Minkels, Floor; de Die-Smulders, Christine EM; for the REGISTRY Investigators of the European Huntington's Disease Network; Registry Steering committee; Bachoud-Lévi, Anne Catherine; Bentivoglio, Anna Rita; Bonelli, Raphael M.; Biunno, Ida; Bronzova, Juliana; Burgunder, Jean Marc; Dunnett, Stephen B.; Ferreira, Joaquim J.; Frich, Jan; Giuliano, Joe; Handley, Olivia J.; Heiberg, Arvid; Illarioshkin, Sergey; Illmann, Torsten; Klempir, Jiri; Milani, Paolo; Cormio, Claudia; Calandra-Buonaura, Giovanna; Capellari, Sabina; Cortelli, Pietro; Poda, Roberto; Language coordinators ; Scaglione, Cesa; Piacentini, Silvia; Romoli, Anna Maria; Sorbi, Sandro; Albanese, Alberto; Castagliuolo, Simona; Castaldo, Anna; Di Donato, Stefano; Di Bella, Daniela; Gellera, Cinzia; Mariotti, Caterina; Nanetti, Lorenzo; Soliveri, Paola; Taroni, Franco; De Michele, Giuseppe; Massarelli, Marco; Russo, Cinzia Valeria; Cannella, Milena; Codella, Valentina; Elifani, Francesca; Petrollini, Martina; Squitieri, Ferdinando; Bentivoglio, Anna Rita; Esposito, Federica.

In: Parkinsonism and Related Disorders, 01.11.2018.

Research output: Contribution to journalArticle

Oosterloo, M, Bijlsma, EK, van Kuijk, SMJ, Minkels, F, de Die-Smulders, CEM, for the REGISTRY Investigators of the European Huntington's Disease Network, Registry Steering committee, Bachoud-Lévi, AC, Bentivoglio, AR, Bonelli, RM, Biunno, I, Bronzova, J, Burgunder, JM, Dunnett, SB, Ferreira, JJ, Frich, J, Giuliano, J, Handley, OJ, Heiberg, A, Illarioshkin, S, Illmann, T, Klempir, J, Milani, P, Cormio, C, Calandra-Buonaura, G, Capellari, S, Cortelli, P, Poda, R, Language coordinators, Scaglione, C, Piacentini, S, Romoli, AM, Sorbi, S, Albanese, A, Castagliuolo, S, Castaldo, A, Di Donato, S, Di Bella, D, Gellera, C, Mariotti, C, Nanetti, L, Soliveri, P, Taroni, F, De Michele, G, Massarelli, M, Russo, CV, Cannella, M, Codella, V, Elifani, F, Petrollini, M, Squitieri, F, Bentivoglio, AR & Esposito, F 2018, 'Clinical and genetic characteristics of late-onset Huntington's disease', Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2018.11.009
Oosterloo M, Bijlsma EK, van Kuijk SMJ, Minkels F, de Die-Smulders CEM, for the REGISTRY Investigators of the European Huntington's Disease Network et al. Clinical and genetic characteristics of late-onset Huntington's disease. Parkinsonism and Related Disorders. 2018 Nov 1. https://doi.org/10.1016/j.parkreldis.2018.11.009
Oosterloo, Mayke ; Bijlsma, Emilia K. ; van Kuijk, Sander MJ ; Minkels, Floor ; de Die-Smulders, Christine EM ; for the REGISTRY Investigators of the European Huntington's Disease Network ; Registry Steering committee ; Bachoud-Lévi, Anne Catherine ; Bentivoglio, Anna Rita ; Bonelli, Raphael M. ; Biunno, Ida ; Bronzova, Juliana ; Burgunder, Jean Marc ; Dunnett, Stephen B. ; Ferreira, Joaquim J. ; Frich, Jan ; Giuliano, Joe ; Handley, Olivia J. ; Heiberg, Arvid ; Illarioshkin, Sergey ; Illmann, Torsten ; Klempir, Jiri ; Milani, Paolo ; Cormio, Claudia ; Calandra-Buonaura, Giovanna ; Capellari, Sabina ; Cortelli, Pietro ; Poda, Roberto ; Language coordinators ; Scaglione, Cesa ; Piacentini, Silvia ; Romoli, Anna Maria ; Sorbi, Sandro ; Albanese, Alberto ; Castagliuolo, Simona ; Castaldo, Anna ; Di Donato, Stefano ; Di Bella, Daniela ; Gellera, Cinzia ; Mariotti, Caterina ; Nanetti, Lorenzo ; Soliveri, Paola ; Taroni, Franco ; De Michele, Giuseppe ; Massarelli, Marco ; Russo, Cinzia Valeria ; Cannella, Milena ; Codella, Valentina ; Elifani, Francesca ; Petrollini, Martina ; Squitieri, Ferdinando ; Bentivoglio, Anna Rita ; Esposito, Federica. / Clinical and genetic characteristics of late-onset Huntington's disease. In: Parkinsonism and Related Disorders. 2018.
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abstract = "Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4{\%}) and 3216 (53.5{\%}) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients.",
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TY - JOUR

T1 - Clinical and genetic characteristics of late-onset Huntington's disease

AU - Oosterloo, Mayke

AU - Bijlsma, Emilia K.

AU - van Kuijk, Sander MJ

AU - Minkels, Floor

AU - de Die-Smulders, Christine EM

AU - for the REGISTRY Investigators of the European Huntington's Disease Network

AU - Registry Steering committee

AU - Bachoud-Lévi, Anne Catherine

AU - Bentivoglio, Anna Rita

AU - Bonelli, Raphael M.

AU - Biunno, Ida

AU - Bronzova, Juliana

AU - Burgunder, Jean Marc

AU - Dunnett, Stephen B.

AU - Ferreira, Joaquim J.

AU - Frich, Jan

AU - Giuliano, Joe

AU - Handley, Olivia J.

AU - Heiberg, Arvid

AU - Illarioshkin, Sergey

AU - Illmann, Torsten

AU - Klempir, Jiri

AU - Milani, Paolo

AU - Cormio, Claudia

AU - Calandra-Buonaura, Giovanna

AU - Capellari, Sabina

AU - Cortelli, Pietro

AU - Poda, Roberto

AU - Language coordinators

AU - Scaglione, Cesa

AU - Piacentini, Silvia

AU - Romoli, Anna Maria

AU - Sorbi, Sandro

AU - Albanese, Alberto

AU - Castagliuolo, Simona

AU - Castaldo, Anna

AU - Di Donato, Stefano

AU - Di Bella, Daniela

AU - Gellera, Cinzia

AU - Mariotti, Caterina

AU - Nanetti, Lorenzo

AU - Soliveri, Paola

AU - Taroni, Franco

AU - De Michele, Giuseppe

AU - Massarelli, Marco

AU - Russo, Cinzia Valeria

AU - Cannella, Milena

AU - Codella, Valentina

AU - Elifani, Francesca

AU - Petrollini, Martina

AU - Squitieri, Ferdinando

AU - Bentivoglio, Anna Rita

AU - Esposito, Federica

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients.

AB - Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients.

KW - Age of onset

KW - Huntington's disease

KW - Late-onset Huntington's disease

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