Clinical and genetic features of familial pituitary adenomas

A. F. Daly, M. L. Jaffrain-Rea, A. Beckers

Research output: Contribution to journalArticlepeer-review

Abstract

Inherited or familial pituitary tumor syndromes such as multiple endocrine neoplasia type 1 and Carney complex provide an important insight into the genetics and molecular pathology of endocrine cancers. Our understanding of these conditions is expanding rapidly due to the identification of the genes and proteins affected and the availability of murine knockout models. The successes achieved to date in understanding multiple endocrine neoplasia type 1 and Carney complex have helped in the identification and study of new inherited pituitary tumor syndromes such as isolated familial somatotropinomas. This review assesses the current status of research into the clinical features, genetics and molecular pathologies of multiple endocrine neoplasia type 1, Carney complex, and isolated familial somatotropinomas, and details ongoing work to delineate familial isolated pituitary adenomas, a potentially new clinical entity.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalHormone and Metabolic Research
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Adenoma
  • Familial
  • Pituitary
  • Tumor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Fingerprint

Dive into the research topics of 'Clinical and genetic features of familial pituitary adenomas'. Together they form a unique fingerprint.

Cite this