Primary lymphedemas are often determined by the mutation of a gene that prevents the receptor of the cell membrane to recognize the growth factors normally circulating. The authors studied the possible genetic mutations present in patients suffering from primary lymphedema, suitably selected from the clinical point of view. Nine genetic mutations have been identified on the genes VEGFR3 and FOXC2. Some of them had never been described in literature. The study is in progress and aims to study the entire families into account that the disease is autosomal dominant with incomplete penetrance.
|Number of pages||6|
|Journal||European Journal of Lymphology and Related Problems|
|Publication status||Published - 2012|
- Primary lymphedema
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine