Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome

Raef H Hajj Ali; Wojciech Zareba; Arthur J. Moss; Peter J. Schwartz; Jesaia Benhorin; G. Michael Vincent; Emanuela H. Locati; Silvia Priori; Carlo Napolitano; Jeffrey A. Towbin; W. Jackson Hall; Jennifer L. Robinson; Mark L. Andrews; Li Zhang; Katherine Timothy; Aharon Medina

doi:10.1016/S0002-9149(99)90772-5

Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome

Raef H Hajj Ali, Wojciech Zareba, Arthur J. Moss, Peter J. Schwartz, Jesaia Benhorin, G. Michael Vincent, Emanuela H. Locati, Silvia Priori, Carlo Napolitano, Jeffrey A. Towbin, W. Jackson Hall, Jennifer L. Robinson, Mark L. Andrews, Li Zhang, Katherine Timothy, Aharon Medina

Research output: Contribution to journal › Article › peer-review

Abstract

In patients with the long QT syndrome (LQTS), the occurrence of cardiac events (syncope or cardiac arrest) is frequently associated with acute arousal caused by exercise, swimming, emotion, or noise. However, cardiac events may also occur during sleep or with ordinary daily activities. The purpose of this study was to determine whether there are differential clinical, electrocardiographic, and genetic features among LQTS patients who experienced cardiac events with and without acute arousal. We identified 1,325 patients with cardiac events from the International LQTS Registry. Based on the precipitating conditions of the first event, 427 patients were classified as arousal, 345 as nonarousal, and the remaining 553 were unknown (not classifiable). Gene linkage was known in 78 of the 772 patients with classifiable first events. The age at first cardiac event was significantly younger in the arousal than the nonarousal group (11.7 vs 15.5 years, respectively; p

Original language	English
Pages (from-to)	457-461
Number of pages	5
Journal	The American Journal of Cardiology
Volume	85
Issue number	4
DOIs	https://doi.org/10.1016/S0002-9149(99)90772-5
Publication status	Published - Feb 15 2000

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(99)90772-5

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Ali, R. H. H., Zareba, W., Moss, A. J., Schwartz, P. J., Benhorin, J., Vincent, G. M., Locati, E. H., Priori, S., Napolitano, C., Towbin, J. A., Hall, W. J., Robinson, J. L., Andrews, M. L., Zhang, L., Timothy, K., & Medina, A. (2000). Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome. The American Journal of Cardiology, 85(4), 457-461. https://doi.org/10.1016/S0002-9149(99)90772-5

Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome. / Ali, Raef H Hajj; Zareba, Wojciech; Moss, Arthur J.; Schwartz, Peter J.; Benhorin, Jesaia; Vincent, G. Michael; Locati, Emanuela H.; Priori, Silvia; Napolitano, Carlo; Towbin, Jeffrey A.; Hall, W. Jackson; Robinson, Jennifer L.; Andrews, Mark L.; Zhang, Li; Timothy, Katherine; Medina, Aharon.

In: The American Journal of Cardiology, Vol. 85, No. 4, 15.02.2000, p. 457-461.

Research output: Contribution to journal › Article › peer-review

Ali, RHH, Zareba, W, Moss, AJ, Schwartz, PJ, Benhorin, J, Vincent, GM, Locati, EH, Priori, S, Napolitano, C, Towbin, JA, Hall, WJ, Robinson, JL, Andrews, ML, Zhang, L, Timothy, K & Medina, A 2000, 'Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome', The American Journal of Cardiology, vol. 85, no. 4, pp. 457-461. https://doi.org/10.1016/S0002-9149(99)90772-5

Ali, Raef H Hajj ; Zareba, Wojciech ; Moss, Arthur J. ; Schwartz, Peter J. ; Benhorin, Jesaia ; Vincent, G. Michael ; Locati, Emanuela H. ; Priori, Silvia ; Napolitano, Carlo ; Towbin, Jeffrey A. ; Hall, W. Jackson ; Robinson, Jennifer L. ; Andrews, Mark L. ; Zhang, Li ; Timothy, Katherine ; Medina, Aharon. / Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome. In: The American Journal of Cardiology. 2000 ; Vol. 85, No. 4. pp. 457-461.

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title = "Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome",

abstract = "In patients with the long QT syndrome (LQTS), the occurrence of cardiac events (syncope or cardiac arrest) is frequently associated with acute arousal caused by exercise, swimming, emotion, or noise. However, cardiac events may also occur during sleep or with ordinary daily activities. The purpose of this study was to determine whether there are differential clinical, electrocardiographic, and genetic features among LQTS patients who experienced cardiac events with and without acute arousal. We identified 1,325 patients with cardiac events from the International LQTS Registry. Based on the precipitating conditions of the first event, 427 patients were classified as arousal, 345 as nonarousal, and the remaining 553 were unknown (not classifiable). Gene linkage was known in 78 of the 772 patients with classifiable first events. The age at first cardiac event was significantly younger in the arousal than the nonarousal group (11.7 vs 15.5 years, respectively; p ",

author = "Ali, {Raef H Hajj} and Wojciech Zareba and Moss, {Arthur J.} and Schwartz, {Peter J.} and Jesaia Benhorin and Vincent, {G. Michael} and Locati, {Emanuela H.} and Silvia Priori and Carlo Napolitano and Towbin, {Jeffrey A.} and Hall, {W. Jackson} and Robinson, {Jennifer L.} and Andrews, {Mark L.} and Li Zhang and Katherine Timothy and Aharon Medina",

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AU - Ali, Raef H Hajj

AU - Zareba, Wojciech

AU - Moss, Arthur J.

AU - Schwartz, Peter J.

AU - Benhorin, Jesaia

AU - Vincent, G. Michael

AU - Locati, Emanuela H.

AU - Priori, Silvia

AU - Napolitano, Carlo

AU - Towbin, Jeffrey A.

AU - Hall, W. Jackson

AU - Robinson, Jennifer L.

AU - Andrews, Mark L.

AU - Zhang, Li

AU - Timothy, Katherine

AU - Medina, Aharon

PY - 2000/2/15

Y1 - 2000/2/15

N2 - In patients with the long QT syndrome (LQTS), the occurrence of cardiac events (syncope or cardiac arrest) is frequently associated with acute arousal caused by exercise, swimming, emotion, or noise. However, cardiac events may also occur during sleep or with ordinary daily activities. The purpose of this study was to determine whether there are differential clinical, electrocardiographic, and genetic features among LQTS patients who experienced cardiac events with and without acute arousal. We identified 1,325 patients with cardiac events from the International LQTS Registry. Based on the precipitating conditions of the first event, 427 patients were classified as arousal, 345 as nonarousal, and the remaining 553 were unknown (not classifiable). Gene linkage was known in 78 of the 772 patients with classifiable first events. The age at first cardiac event was significantly younger in the arousal than the nonarousal group (11.7 vs 15.5 years, respectively; p

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Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome

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