Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with the long QT syndrome

Raef H Hajj Ali, Wojciech Zareba, Arthur J. Moss, Peter J. Schwartz, Jesaia Benhorin, G. Michael Vincent, Emanuela H. Locati, Silvia Priori, Carlo Napolitano, Jeffrey A. Towbin, W. Jackson Hall, Jennifer L. Robinson, Mark L. Andrews, Li Zhang, Katherine Timothy, Aharon Medina

Research output: Contribution to journalArticlepeer-review

Abstract

In patients with the long QT syndrome (LQTS), the occurrence of cardiac events (syncope or cardiac arrest) is frequently associated with acute arousal caused by exercise, swimming, emotion, or noise. However, cardiac events may also occur during sleep or with ordinary daily activities. The purpose of this study was to determine whether there are differential clinical, electrocardiographic, and genetic features among LQTS patients who experienced cardiac events with and without acute arousal. We identified 1,325 patients with cardiac events from the International LQTS Registry. Based on the precipitating conditions of the first event, 427 patients were classified as arousal, 345 as nonarousal, and the remaining 553 were unknown (not classifiable). Gene linkage was known in 78 of the 772 patients with classifiable first events. The age at first cardiac event was significantly younger in the arousal than the nonarousal group (11.7 vs 15.5 years, respectively; p

Original languageEnglish
Pages (from-to)457-461
Number of pages5
JournalThe American Journal of Cardiology
Volume85
Issue number4
DOIs
Publication statusPublished - Feb 15 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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