The hematological and clinical data in 254 Italian subjects with β thalassemia trait are reported. 46% of the patients were anemic, 40% complained of weakness, 19% showed enlargement of the spleen and 10% enlargement of the liver. The hemoglobin levels ranged from 8 to 15.5 g/dl with a normal distribution and a mean of 12.73 for males, 10.93 for females and 11.34 for children (4-15 yr). Reticulocyte counts and serum bilirubin levels were slightly increased and both showed a statistically significant relationship with hemoglobin levels. The serum iron level was increased in 27% and decreased in 6% of the cases. Hemoglobin A2 concentrations ranged from 3.5 to 8% with a normal distribution and a mean of 5.37; Hb F values were less than 1% in 36% and varied from 1 to 14% in the remainder. Red cell osmotic fragility was decreased in all but 6% of the subjects: low MCV, MCH and MCHC values were observed in 75%, 86% and 10% respectively. A comparison is made between the data and those obtained by other workers.
|Number of pages||9|
|Journal||British Journal of Haematology|
|Publication status||Published - 1976|
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