Clinical and haematological data in 254 cases of beta thalassaemia trait in Italy

U. Mazza, G. Saglio, F. Caligaris Cappio, C. Camaschella, G. Neretto, E. Gallo

Research output: Contribution to journalArticlepeer-review

Abstract

The hematological and clinical data in 254 Italian subjects with β thalassemia trait are reported. 46% of the patients were anemic, 40% complained of weakness, 19% showed enlargement of the spleen and 10% enlargement of the liver. The hemoglobin levels ranged from 8 to 15.5 g/dl with a normal distribution and a mean of 12.73 for males, 10.93 for females and 11.34 for children (4-15 yr). Reticulocyte counts and serum bilirubin levels were slightly increased and both showed a statistically significant relationship with hemoglobin levels. The serum iron level was increased in 27% and decreased in 6% of the cases. Hemoglobin A2 concentrations ranged from 3.5 to 8% with a normal distribution and a mean of 5.37; Hb F values were less than 1% in 36% and varied from 1 to 14% in the remainder. Red cell osmotic fragility was decreased in all but 6% of the subjects: low MCV, MCH and MCHC values were observed in 75%, 86% and 10% respectively. A comparison is made between the data and those obtained by other workers.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalBritish Journal of Haematology
Volume33
Issue number1
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Hematology

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