Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C

C. Panella; A. Francavilla; D. Conte; I. Tatulli; F. Rubini

doi:10.1136/gut.34.2_Suppl.S127

Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C

C. Panella, A. Francavilla, D. Conte, I. Tatulli, F. Rubini

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Abstract

In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.

Original language	English
Journal	Gut
Volume	34
Issue number	2 SUPPL
DOIs	https://doi.org/10.1136/gut.34.2_Suppl.S127
Publication status	Published - 1993

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Gastroenterology

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10.1136/gut.34.2_Suppl.S127

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AU - Conte, D.

AU - Tatulli, I.

AU - Rubini, F.

PY - 1993

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AB - In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.

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Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C

Abstract

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