Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C

C. Panella, A. Francavilla, D. Conte, I. Tatulli, F. Rubini

Research output: Contribution to journalArticle

Abstract

In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.

Original languageEnglish
JournalGut
Volume34
Issue number2 SUPPL
DOIs
Publication statusPublished - 1993

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interferon alfa-2b
Chronic Hepatitis C
Chronic Hepatitis
Hepatitis C
Alanine Transaminase
Therapeutics
Inflammation
Biopsy
Liver

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C. / Panella, C.; Francavilla, A.; Conte, D.; Tatulli, I.; Rubini, F.

In: Gut, Vol. 34, No. 2 SUPPL, 1993.

Research output: Contribution to journalArticle

Panella, C. ; Francavilla, A. ; Conte, D. ; Tatulli, I. ; Rubini, F. / Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C. In: Gut. 1993 ; Vol. 34, No. 2 SUPPL.
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