Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C

C. Panella, A. Francavilla, D. Conte, I. Tatulli, F. Rubini

Research output: Contribution to journalArticlepeer-review

Abstract

In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.

Original languageEnglish
JournalGut
Volume34
Issue number2 SUPPL
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

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