Abstract
Objective: To find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search for a correlation between the impact of symptoms. Patients and methods: Fifty-seven consecutive patients underwent cystoscopy under anaesthesia to classify those cases suspected of being affected with BPS/IC. The time elapsed between onset of symptoms and diagnosis at the time of bladder biopsy was also defined as BPS/IC duration. Bladder biopsies were taken including detrusor muscle, three deep cold biopsies of posterior, anterior and lateral bladder wall. Results: Statistical analysis showed significant correlation between BPS/IC duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be related to BPS/IC duration. Thus an early diagnosis allows an appropriate therapeutic approach to be started to prevent a more severe evolution of this multifaceted painful syndrome. Conclusions: Our study shows a correlation between the time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. BPS/IC duration did not seem to correlate with the severity of symptoms, but rather with the presence of associated diseases. Level of evidence: Not applicable for this multicentre audit.
| Original language | English |
|---|---|
| Pages (from-to) | 248-253 |
| Number of pages | 6 |
| Journal | Journal of Clinical Urology |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2018 |
| Externally published | Yes |
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Keywords
- Bladder biopsy
- bladder pain syndrome
- BPS/IC
- chronic pelvic pain
- interstitial cystitis
ASJC Scopus subject areas
- Surgery
- Urology
Cite this
Clinical and histological findings in bladder pain syndrome/interstitial cystitis : The implication of time of symptoms. / Porru, Daniele; Bobbi, Valentina; Di Franco, Carmelo; Viglio, Alessandra; Novario, Mattia; Tinelli, Carmine; Gardella, Barbara; Nappi, Rossella; Spinillo, Arsenio; Paulli, Marco; Rovereto, Bruno.
In: Journal of Clinical Urology, Vol. 11, No. 4, 01.07.2018, p. 248-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and histological findings in bladder pain syndrome/interstitial cystitis
T2 - The implication of time of symptoms
AU - Porru, Daniele
AU - Bobbi, Valentina
AU - Di Franco, Carmelo
AU - Viglio, Alessandra
AU - Novario, Mattia
AU - Tinelli, Carmine
AU - Gardella, Barbara
AU - Nappi, Rossella
AU - Spinillo, Arsenio
AU - Paulli, Marco
AU - Rovereto, Bruno
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objective: To find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search for a correlation between the impact of symptoms. Patients and methods: Fifty-seven consecutive patients underwent cystoscopy under anaesthesia to classify those cases suspected of being affected with BPS/IC. The time elapsed between onset of symptoms and diagnosis at the time of bladder biopsy was also defined as BPS/IC duration. Bladder biopsies were taken including detrusor muscle, three deep cold biopsies of posterior, anterior and lateral bladder wall. Results: Statistical analysis showed significant correlation between BPS/IC duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be related to BPS/IC duration. Thus an early diagnosis allows an appropriate therapeutic approach to be started to prevent a more severe evolution of this multifaceted painful syndrome. Conclusions: Our study shows a correlation between the time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. BPS/IC duration did not seem to correlate with the severity of symptoms, but rather with the presence of associated diseases. Level of evidence: Not applicable for this multicentre audit.
AB - Objective: To find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search for a correlation between the impact of symptoms. Patients and methods: Fifty-seven consecutive patients underwent cystoscopy under anaesthesia to classify those cases suspected of being affected with BPS/IC. The time elapsed between onset of symptoms and diagnosis at the time of bladder biopsy was also defined as BPS/IC duration. Bladder biopsies were taken including detrusor muscle, three deep cold biopsies of posterior, anterior and lateral bladder wall. Results: Statistical analysis showed significant correlation between BPS/IC duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be related to BPS/IC duration. Thus an early diagnosis allows an appropriate therapeutic approach to be started to prevent a more severe evolution of this multifaceted painful syndrome. Conclusions: Our study shows a correlation between the time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. BPS/IC duration did not seem to correlate with the severity of symptoms, but rather with the presence of associated diseases. Level of evidence: Not applicable for this multicentre audit.
KW - Bladder biopsy
KW - bladder pain syndrome
KW - BPS/IC
KW - chronic pelvic pain
KW - interstitial cystitis
UR - http://www.scopus.com/inward/record.url?scp=85049885261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049885261&partnerID=8YFLogxK
U2 - 10.1177/2051415817747474
DO - 10.1177/2051415817747474
M3 - Article
AN - SCOPUS:85049885261
VL - 11
SP - 248
EP - 253
JO - Journal of Clinical Urology
JF - Journal of Clinical Urology
SN - 2051-4158
IS - 4
ER -