Clinical and histological findings in bladder pain syndrome/interstitial cystitis: The implication of time of symptoms

Daniele Porru, Valentina Bobbi, Carmelo Di Franco, Alessandra Viglio, Mattia Novario, Carmine Tinelli, Barbara Gardella, Rossella Nappi, Arsenio Spinillo, Marco Paulli, Bruno Rovereto

Research output: Contribution to journalArticlepeer-review


Objective: To find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search for a correlation between the impact of symptoms. Patients and methods: Fifty-seven consecutive patients underwent cystoscopy under anaesthesia to classify those cases suspected of being affected with BPS/IC. The time elapsed between onset of symptoms and diagnosis at the time of bladder biopsy was also defined as BPS/IC duration. Bladder biopsies were taken including detrusor muscle, three deep cold biopsies of posterior, anterior and lateral bladder wall. Results: Statistical analysis showed significant correlation between BPS/IC duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be related to BPS/IC duration. Thus an early diagnosis allows an appropriate therapeutic approach to be started to prevent a more severe evolution of this multifaceted painful syndrome. Conclusions: Our study shows a correlation between the time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. BPS/IC duration did not seem to correlate with the severity of symptoms, but rather with the presence of associated diseases. Level of evidence: Not applicable for this multicentre audit.

Original languageEnglish
Pages (from-to)248-253
Number of pages6
JournalJournal of Clinical Urology
Issue number4
Publication statusPublished - Jul 1 2018
Externally publishedYes


  • Bladder biopsy
  • bladder pain syndrome
  • BPS/IC
  • chronic pelvic pain
  • interstitial cystitis

ASJC Scopus subject areas

  • Surgery
  • Urology


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