Clinical and hormonal aspects of male hypogonadism in myotonic dystrophy

I. Mastrogiacomo, G. Bonanni, E. Menegazzo, C. Santarossa, E. Pagani, M. Gennarelli, C. Angelini

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Abstract

In order to study male hypergonadotropic hypogonadism as completely as possible, and to evaluate its possible effects on muscle atrophy and sexuality, RIA or IRMA methods were used to measure the levels of luteinizing hormonc (LH), follicle stimulating hormone (FSH), prolactin, total (T) and free (FT) testosterone, estradiol (E), dihydrotestosterone (DHT), sex hormone binding globulin (SHBG), androstenedione (A) and 17-OH-progesterone (17-OH-P) in 29 patients with myotonic dystrophy (MD). The mean hormonal levels ±SD were: LH 8.0 ± 4.4 mIU/ml, FSH 17.4 ± 11.5 mIU/ml, A 200 ± 130 ng/dl (all higher than in controls); T 406 ± 290 ng/dl, FT 22.7 ± 7.0 pg/ml, DHT 55.5 ± 29.7 ng/ml (all lower than in controls). The low FT and DHT levels (never previously studied in MD) confirm the androgenic deficiency. The high androstenedione levels and low testosterone concentrations suggest defective enzyme 17-dehydrogenase. The duration of the disease correlated with both testosterone (r = -0.56) and FT levels (r = -0.59), showing that hypogonadism tends to worsen progressively. When the patients were divided into three groups on the basis of the severity of muscle involvement (A, B and C), LH and FSH levels were higher in group C (more severe disease) than in group A, respectively 9.3 ± 4.7 and 20.6 ± 12.3 mIU/ml versus 4.8 ± 0.9 and 8.4 ± 3.8, p <0.03; T levels were lower in group C than in group A, 337.3 ± 263.4 ng/dl versus 649.7 ± 320.3 (p <0.03); however, there was no significant difference in the FT levels of the three groups, which may imply that hypogonadism is unlikely to have a direct effect on muscle atrophy. About 25% of our patients were impotent; these subjects had higher LH and FSH (p <0.001) and lower FT levels than the patients who were not impotent (p <0.03). However, hypogonadism may not be the only cause of impotence as all of the impotent patients belonged to group C and had a very high (CTG)n triplet expansion. We hypothesise that hypogonadism and sexual impairment could be partially due to a muscle cell alteration: i.e. a dysfunction of both the testicular peritubular myoid cells and of the corpus cavernosum smooth muscle.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume17
Issue number1
DOIs
Publication statusPublished - 1996

Keywords

  • androstenedione
  • dihydrotestosterone
  • gonadotropins
  • hypogon adism
  • impotence
  • male
  • myotonic dystrophy
  • testosterone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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    Mastrogiacomo, I., Bonanni, G., Menegazzo, E., Santarossa, C., Pagani, E., Gennarelli, M., & Angelini, C. (1996). Clinical and hormonal aspects of male hypogonadism in myotonic dystrophy. Italian Journal of Neurological Sciences, 17(1), 59-65. https://doi.org/10.1007/BF01995710