Clinical and imaging characterization of a patient with idiopathic progressive ataxia and palatal tremor

R. Cilia, A. Righini, G. Marotta, R. Benti, R. Marconi, I. U. Isaias, G. Pezzoli, A. Antonini

Research output: Contribution to journalArticlepeer-review

Abstract

We describe clinical and imaging features of a patient with sporadic progressive ataxia and palatal tremor (PAPT) of unknown etiology. There was hypertrophy of bilateral inferior olivary nuclei with hyperintense T2-weighted signal and mild cerebellar atrophy at brain magnetic resonance imaging. 18F-fluoro-2-desoxy-d-glucose positron emission tomography scanning (FDG-PET) showed hypometabolism in the red nucleus, external globus pallidus and precuneus while FP-CIT-SPECT imaging revealed mild and progressive loss of striatal dopaminergic terminals. Our findings suggest that in idiopathic PAPT involvement of the dentato-rubro-olivary pathway occurs along with some dopaminergic dysfunction.

Original languageEnglish
Pages (from-to)944-946
Number of pages3
JournalEuropean Journal of Neurology
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • [123I]FP-CIT SPECT
  • [18F]FDG-PET
  • Ataxia
  • Hypertrophic olivary degeneration
  • Palatal tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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