Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis

Samuele E. Burastero; G. Mistrello; C. Paolucci; D. Breda; D. Roncarolo; S. Zanotta; P. Falagiani

Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis

Samuele E. Burastero, G. Mistrello, C. Paolucci, D. Breda, D. Roncarolo, S. Zanotta, P. Falagiani

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p

Original language	English
Pages (from-to)	343-352
Number of pages	10
Journal	International Journal of Immunopathology and Pharmacology
Volume	22
Issue number	2
Publication status	Published - Apr 2009

Keywords

Allergoid
Birch allergy
IL-10
Immune response
Sublingual immunotherapy

ASJC Scopus subject areas

Pharmacology
Immunology
Immunology and Allergy

Access to Document

Fingerprint Dive into the research topics of 'Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis'. Together they form a unique fingerprint.

Cite this

Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis. / Burastero, Samuele E.; Mistrello, G.; Paolucci, C.; Breda, D.; Roncarolo, D.; Zanotta, S.; Falagiani, P.

In: International Journal of Immunopathology and Pharmacology, Vol. 22, No. 2, 04.2009, p. 343-352.

Research output: Contribution to journal › Article › peer-review

Burastero, Samuele E. ; Mistrello, G. ; Paolucci, C. ; Breda, D. ; Roncarolo, D. ; Zanotta, S. ; Falagiani, P. / Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis. In: International Journal of Immunopathology and Pharmacology. 2009 ; Vol. 22, No. 2. pp. 343-352.

@article{b9ac04315580409db198567d3d3e4c78,

title = "Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis",

abstract = "Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p",

keywords = "Allergoid, Birch allergy, IL-10, Immune response, Sublingual immunotherapy",

author = "Burastero, {Samuele E.} and G. Mistrello and C. Paolucci and D. Breda and D. Roncarolo and S. Zanotta and P. Falagiani",

year = "2009",

month = apr,

language = "English",

volume = "22",

pages = "343--352",

journal = "International Journal of Immunopathology and Pharmacology",

issn = "0394-6320",

publisher = "Biomedical Research Press s.a.s.",

number = "2",

}

TY - JOUR

T1 - Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis

AU - Burastero, Samuele E.

AU - Mistrello, G.

AU - Paolucci, C.

AU - Breda, D.

AU - Roncarolo, D.

AU - Zanotta, S.

AU - Falagiani, P.

PY - 2009/4

Y1 - 2009/4

N2 - Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p

AB - Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p

KW - Allergoid

KW - Birch allergy

KW - IL-10

KW - Immune response

KW - Sublingual immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=67650501126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650501126&partnerID=8YFLogxK

M3 - Article

C2 - 19505388

AN - SCOPUS:67650501126

VL - 22

SP - 343

EP - 352

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 2

ER -