Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis

Samuele E. Burastero, G. Mistrello, C. Paolucci, D. Breda, D. Roncarolo, S. Zanotta, P. Falagiani

Research output: Contribution to journalArticlepeer-review

Abstract

Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p

Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume22
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • Allergoid
  • Birch allergy
  • IL-10
  • Immune response
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis'. Together they form a unique fingerprint.

Cite this