Abstract
Sublingual immunotherapy is safe and efficacious in the treatment of patients with allergic rhinitis. The clinical and biological efficacy of modified allergens (allergoids) has not been fully clarified. We investigated in birch allergic patients the effect of a pre-co-seasonal sublingual immunotherapy regimen with a modified allergen extract on clinical parameters and on T cell proliferation and regulatory cytokine production (IL-10, TGF-beta). We found that during the birch pollen season symptoms and drug usage scores were 30 and 40% improved, respectively, in treated versus control subjects (p
Original language | English |
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Pages (from-to) | 343-352 |
Number of pages | 10 |
Journal | International Journal of Immunopathology and Pharmacology |
Volume | 22 |
Issue number | 2 |
Publication status | Published - Apr 2009 |
Keywords
- Allergoid
- Birch allergy
- IL-10
- Immune response
- Sublingual immunotherapy
ASJC Scopus subject areas
- Pharmacology
- Immunology
- Immunology and Allergy