Clinical and instrumental evaluation of the efficacy of a nanosilicon containing formulation

Enzo Berardesca, Manuela Carrera

Research output: Contribution to journalArticlepeer-review


Silicon is a component of elastin and collagen and increasing evidence suggests that silicon is a nutrient of concern for both bone and skin. It has been proven that silicon deprivation affects collagen formation and collagen deposition in many tissues. The main source of silicon is the diet, but the bioavailability of this nutrient from solid foods is not assessed. The transformation of silicon contained in zeolite by means of nanotechnology has led to the production of nanosilicon. The particles of nanosilicon raise dimensions of 10-20 nm with an increased active surface and a higher bioavailability which facilitate the cellular absorption. Nanosilicon is very important in skin hydration because of its capacity to bind a large amount of water and to normalize the contents of glycosaminoglycan. This study has been undertaken in order to evaluate the efficacy of a nanosilicon containing formulation to improve skin hydration and elasticity. Thirty healthy female subjects entered the study. Fifteen patients were randomized to receive the placebo and fifteen patients received the active compound; all the patients were instructed to take the food supplement twice a day for the first twenty days and then once a day for the next twenty days. All the patients enrolled were instructed to apply the nanosilicon containing solution on the right forearm four times a day. The patients were evaluated with non invasive methods at baseline, after 20 days and at the end of the study, after 40 days. Statistical analysis was performed using t-test and Anova and values of p <0.05 were considered statistically significant. After twenty days in both groups there was a statistically significant improvement of skin hydration on the tight forearm as well as a significant improvement of the barrier function as shown by the decrease of the TEWL. The elasticity was increased only in the group who take the active compound and the results were statistically significant. The evaluation performed at the end of the study confirmed this trend. The consumption of the food supplement and the topical use of the solution both containing nanosilicon has proven to be effective for the improvement of skin hydration, barrier function and elasticity.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJournal of Plastic Dermatology
Issue number1
Publication statusPublished - Jan 2009


  • Nanosilicon
  • Skin hydration and elasticity

ASJC Scopus subject areas

  • Dermatology


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