Clinical and instrumental evaluation of the efficacy of a new depigmenting agent containing a combination of a retinoid, a phenolic agent and an antioxidant for the treatment of solar lentigines

Norma Cameli, Elva Abril, Marina Agozzino, Maria Mariano

Research output: Contribution to journalArticle

Abstract

Background: Solar lentigines are common benign macular hyperpigmented lesions localized on sun-exposed areas. Objective: To evaluate the efficacy and safety of a new depigmenting agent containing a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a reducing agent (δ-tocopheryl-β-D-glucopyranoside) in the topical treatment of solar lentigines. Patients and Methods: Twenty patients with solar lentigines of the face and hands applied the depigmenting agent on each lentigo once daily for 12 weeks. The outcome was evaluated at 45 days (T1) and 3 months (T2) after the end of treatment compared to baseline (T0) by means of clinical evaluation, Mexameter® and Visioface devices for digital and ultraviolet computerized image analysis of skin color as well as in vivo reflectance confocal microscopy. Results: Image analysis and confocal laser reflectance microscopy showed that hyperpigmentation was significantly reduced at T2 compared to baseline and to controls. Conclusion: The study treatment was well tolerated and showed significant improvement in the depigmentation of solar lentigines.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalDermatology
Volume230
Issue number4
DOIs
Publication statusPublished - May 28 2015

Keywords

  • Confocal laser reflectance microscopy
  • Depigmenting agent
  • Non-invasive diagnosis
  • Solar lentigines

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Clinical and instrumental evaluation of the efficacy of a new depigmenting agent containing a combination of a retinoid, a phenolic agent and an antioxidant for the treatment of solar lentigines'. Together they form a unique fingerprint.

  • Cite this