Clinical and laboratory features predicting a favorable outcome and allowing early discharge in cancer patients with low-risk febrile neutropenia: A literature review

E. Castagnola, D. Paola, R. Giacchino, C. Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

To value feasibility of early discharge in febrile granulocytopenic patients, 27 original paper published in the last 11 years were analyzed concerning these clinical and therapeutic approaches. A Medline search of English language literature published in the last 11 years (1988-1999) used the key words neutropenia, fever, cancer, home-antibiotic therapy, short course of antibiotic therapy, and early discharge. Twenty-seven original papers fulfilling the study criteria were identified. In these studies, 5208 episodes were evaluated: there were 538 failures with 87 deaths. Features of lowrisk patients who developed life-threatening infectious disease were related to general clinical condition, cancer control, bone marrow function, presence of clinical signs of infection, and social features. Careful risk assessment can allow safe recognition of low-risk patients with febrile neutropenia who can be discharged early and can be used to follow outpatient treatment programs to improve patients' quality of life as well as the use of economic resources.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalJournal of Hematotherapy and Stem Cell Research
Volume9
Issue number5
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Hematology
  • Immunology

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