Clinical and laboratory parameters that define clinically relevant B-CLL subgroups

N. Chiorazzi, S. L. Allen, M. Ferrarini

Research output: Contribution to journalArticle


B cell-type chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease. This is reflected by the very wide-ranging clinical courses that B-CLL patients experience and by the marked variation in laboratory findings between patients. In this chapter, we will review the various clinical and laboratory parameters that divide B-CLL patients into "subgroups," and correlate the parameters that define them. When feasible, we will also link clinical features to the cellular and genetic characteristics recently defined for these leukemic cells. The discussion is limited to parameters that define phenotypes or subgroups that may relate to disease activity and clinical outcome.

Original languageEnglish
Pages (from-to)109-133
Number of pages25
JournalCurrent Topics in Microbiology and Immunology
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology
  • Immunology and Allergy
  • Microbiology (medical)

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