Clinical and metabolic effects of drospirenone-estradiol in menopausal women: A prospective study

M. Gambacciani, G. Rosano, B. Cappagli, A. Pepe, C. Vitale, A. R. Genazzani

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives To describe the effects of low-dose hormonal replacement therapy (HRT) on quality of life, metabolic parameters and blood pressure in postmenopausal women. Methods Postmenopausal women untreated with HRT or sex steroids in the previous 12 months were randomized to treatment with 17β-estradiol (1mg/day) plus drospirenone (2mg/day) (E2++DRSP) or to calcium (controls). Quality of life was evaluated by the Women's Health Questionnaire (WHQ) at baseline and after 6 and 12 weeks of treatment. Anthropometric, metabolic and blood pressure measurements were performed before and after 3 months of treatment. Results WHQ domain scores for vasomotor and somatic symptoms, anxiety/fears, depressed mood, sexual behavior and sleep problems decreased significantly in the E2++DRSP group relative to both baseline and control values (p

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalClimacteric
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 2011

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Estradiol
Prospective Studies
Women's Health
Quality of Life
Blood Pressure
Therapeutics
Sexual Behavior
Fear
Sleep
Anxiety
Steroids
drospirenone
Calcium
Surveys and Questionnaires

Keywords

  • blood pressure
  • hormone replacement therapy
  • insulin sensitivity
  • Menopause
  • quality of life

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Clinical and metabolic effects of drospirenone-estradiol in menopausal women : A prospective study. / Gambacciani, M.; Rosano, G.; Cappagli, B.; Pepe, A.; Vitale, C.; Genazzani, A. R.

In: Climacteric, Vol. 14, No. 1, 02.2011, p. 18-24.

Research output: Contribution to journalArticle

Gambacciani, M. ; Rosano, G. ; Cappagli, B. ; Pepe, A. ; Vitale, C. ; Genazzani, A. R. / Clinical and metabolic effects of drospirenone-estradiol in menopausal women : A prospective study. In: Climacteric. 2011 ; Vol. 14, No. 1. pp. 18-24.
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