Clinical and molecular characteristics of lymphoplasmacytic lymphoma not associated with an IgM monoclonal protein: A multicentric study of the Rete Ematologica Lombarda (REL) network

Marzia Varettoni, Emanuela Boveri, Silvia Zibellini, Alessandra Tedeschi, Chiara Candido, Virginia Valeria Ferretti, Ettore Rizzo, Elisa Doni, Michele Merli, Lucia Farina, Maria Goldaniga, Anna Gallì, Sara Rattotti, Anna Maria Frustaci, Marina Deodato, Laura Bandiera, Giuseppe Isimbaldi, Silvia Uccella, Antonello Domenico Cabras, Umberto GianelliLuca Baldini, Marco Paulli, Luca Arcaini

Research output: Contribution to journalArticle

Abstract

Lymphoplasmacytic lymphoma (LPL) is usually associated with a serum IgM paraprotein, corresponding to Waldenström's Macroglobulinemia (WM). Cases presenting with IgG or IgA, or without a monoclonal protein are extremely rare. We analyzed clinical characteristics, frontline treatment, and the outcome of 45 patients with non-IgM LPL, and compared them with a control group of WM patients. The median age was similar, with significantly higher prevalence of females in non-IgM LPL, than in WM patients (60% vs 39%, P = .016). Patients with non-IgM LPL more frequently presented with lymphadenopathies (53% vs 15%, P
Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalAmerican Journal of Hematology
Volume94
Issue number11
DOIs
Publication statusPublished - Nov 2019

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