Clinical and molecular observations of two fatal cases of rotavirus-associated enteritis in children in Italy

Maria Cristina Medici, Laura Anna Abelli, Monica Martinelli, Domenico Corradi, Icilio Dodi, Fabio Tummolo, Valeria Albonetti, Vito Martella, Giuseppe Dettori, Carlo Chezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Two fatal cases of infantile rotavirus enteritis occurred in northern Italy in 2005. Both children were severely dehydrated, and death was related to severe cerebral edema. Histological examination demonstrated extensive damage of the intestinal epithelium, villous atrophy or blunting, and macrophage infiltration. The two rotavirus strains were of the G1P[8] type and the long electropherotype. The 2005 G1P[8] rotaviruses differed in the NSP4, VP3, VP4, and VP7 genes from G1P[8] rotaviruses circulating in 2004, suggesting the onset of a new G1P[8] strain in the local population.

Original languageEnglish
Pages (from-to)2733-2739
Number of pages7
JournalJournal of Clinical Microbiology
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 2011

ASJC Scopus subject areas

  • Microbiology (medical)

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