Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients - An open, multicenter study

M. G. Agresti, F. de Bernardis, F. Mondello, R. Bellocco, G. P. Carosi, R. M. Caputo, F. Milazzo, F. Chiodo, V. Giannini, L. Minoli, L. Ortona, G. Pastore, M. Piazza, G. Scalise, A. Cirelli, A. Chiesi, D. Greco, S. Vella, A. Cassone

Research output: Contribution to journalArticlepeer-review

Abstract

A prospective, multicenter, open study of fluconazole prophylaxis was performed in AIDS patients to evaluate the efficacy and toxicity of the drug in preventing relapses of esophageal candidiasis. To this aim, 99 AIDS patients who presented a first episode of clinically and microbiologically confirmed esophageal candidiasis were enrolled in eleven clinical centers scattered throughout the Italian territory. After resolution of this initial esophagitis, all subjects were given fluconazole, 100 mg/die, and followed up for a 6 month period. Only 7 out of the 99 patients enrolled had a relapse of Candida esophagitis, during a mean follow-up period of 138.5 days. All relapsing patients had CD4+ cell number 100 CD4+/μl. However, the data on Candida antigenemia in these patients invite the consideration of a relative inefficiency of the drug to eradicate the microrganism from the esophageal tissue.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalEuropean Journal of Epidemiology
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 1994

Keywords

  • AIDS
  • Candida
  • Candidal esophagitis
  • Fluconazole prophylaxis
  • Italy

ASJC Scopus subject areas

  • Epidemiology

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