Abstract
A prospective, multicenter, open study of fluconazole prophylaxis was performed in AIDS patients to evaluate the efficacy and toxicity of the drug in preventing relapses of esophageal candidiasis. To this aim, 99 AIDS patients who presented a first episode of clinically and microbiologically confirmed esophageal candidiasis were enrolled in eleven clinical centers scattered throughout the Italian territory. After resolution of this initial esophagitis, all subjects were given fluconazole, 100 mg/die, and followed up for a 6 month period. Only 7 out of the 99 patients enrolled had a relapse of Candida esophagitis, during a mean follow-up period of 138.5 days. All relapsing patients had CD4+ cell number 100 CD4+/μl. However, the data on Candida antigenemia in these patients invite the consideration of a relative inefficiency of the drug to eradicate the microrganism from the esophageal tissue.
Original language | English |
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Pages (from-to) | 17-22 |
Number of pages | 6 |
Journal | European Journal of Epidemiology |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 1994 |
Keywords
- AIDS
- Candida
- Candidal esophagitis
- Fluconazole prophylaxis
- Italy
ASJC Scopus subject areas
- Epidemiology