Clinical and neurophysiological outcome of surgery in extreme carpal tunnel syndrome

M. Mondelli, F. Reale, R. Padua, I. Aprile, L. Padua

Research output: Contribution to journalArticlepeer-review


Introduction: Surgical release is the most effective therapy for the symptoms of carpal tunnel syndrome (CTS). It is widely considered that surgery may be ineffective in 'extreme' cases (those with atrophy of the thenar eminence muscles and no sensory and motor response of the median nerve). Objective: To report clinical and eletrophysiological outcome of 10 subjects with 'extreme' CTS surgically treated. Methods: Ten hands belonging to 10 patients (9 women and one man, mean age 65 years) underwent surgical release by the mini-incision of the palm technique. All showed atrophy of thenar eminence and absence of motor and sensory responses of the median nerve. The protocol consisted of clinical and electrophysiological evaluation, with the patient completing the self-administered Boston questionnaire (BQ) before the operation and one and 6 months after it. Results: After surgical release, all patients reported an absence of pain and disappearance or reduction of paraesthesia. Six months after the operation, motor and sensory responses of the median nerve returned in 8 and 5 hands, respectively. The BQ showed a significant improvement in symptom and functional scores, although muscle atrophy remained unchanged. No correlation was found between the degree of clinical and electrical improvement and the age of the patients. Conclusion: It is possible to obtain good clinical and electrophysiological results even in extreme cases of CTS.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalClinical Neurophysiology
Issue number7
Publication statusPublished - 2001


  • Boston Questionnaire
  • Extreme carpal tunnel syndrome
  • Nerve conduction study
  • Outcome
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)


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