TY - JOUR
T1 - Clinical and patient-reported outcomes after pancreatoduodenectomy for different diseases
T2 - A follow-up study
AU - Pezzilli, Raffaele
AU - Falconi, Massimo
AU - Zerbi, Alessandro
AU - Casadei, Riccardo
AU - Valli, Luana
AU - Varale, Roberta
AU - Armatura, Giulia
AU - Felicani, Cristina
AU - Morselli-Labate, Antonio M.
PY - 2011/8
Y1 - 2011/8
N2 - Objective: The objective of the study was to evaluate clinical features and quality of life (QoL) in a 2-year follow-up study in subjects who underwent pancreatic head resection (PHR). Methods: One hundred ninety-seven patients with benign and malignant diseases who underwent PHR were studied. A dedicated clinical form and the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire C-30 were administered at evaluation times (immediately before surgery and 6, 12, 18, and 24 months after discharge). A sample of 197 sex- and age-matched norms was also included into the study as reference group. Results: Of the 197 patients studied, 164 (83.2%) had malignant disease, and 33 had benign disease (16.8%). At initial evaluation, global health was significantly lower (P = 0.001) in the study population as compared with the norms. At the end of the study, the QoL was not significantly different from the norms, although the QoL of the 30 patients with benign disease was significantly better than that of the 72 patients with malignant disease. Conclusions: The QoL before PHR was impaired in study patients before resection as compared with the normative population, whereas in patients who survived resection, it significantly improved in the 24 months after surgery.
AB - Objective: The objective of the study was to evaluate clinical features and quality of life (QoL) in a 2-year follow-up study in subjects who underwent pancreatic head resection (PHR). Methods: One hundred ninety-seven patients with benign and malignant diseases who underwent PHR were studied. A dedicated clinical form and the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire C-30 were administered at evaluation times (immediately before surgery and 6, 12, 18, and 24 months after discharge). A sample of 197 sex- and age-matched norms was also included into the study as reference group. Results: Of the 197 patients studied, 164 (83.2%) had malignant disease, and 33 had benign disease (16.8%). At initial evaluation, global health was significantly lower (P = 0.001) in the study population as compared with the norms. At the end of the study, the QoL was not significantly different from the norms, although the QoL of the 30 patients with benign disease was significantly better than that of the 72 patients with malignant disease. Conclusions: The QoL before PHR was impaired in study patients before resection as compared with the normative population, whereas in patients who survived resection, it significantly improved in the 24 months after surgery.
KW - chronic pancreatitis
KW - diagnosis
KW - disease management
KW - pancreatic neoplasms
KW - patient-reported outcome
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U2 - 10.1097/MPA.0b013e318216f693
DO - 10.1097/MPA.0b013e318216f693
M3 - Article
C2 - 21562441
AN - SCOPUS:80051546265
VL - 40
SP - 938
EP - 945
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 6
ER -