Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone

B. Rousselin, D. Vanel, M. J. Terrier-Lacombe, B. J M Istria, M. Spielman, J. Masselot

Research output: Contribution to journalArticle

Abstract

Radiographs and clinical charts were reviewed in a series of 13 cases of primary neuroectodermal bone tumors, involving 9 males and 4 females, aged from 3 to 32 years (average: 15 years). The average delay between the onset and diagnosis was 5 months. Fever and other systemic symptoms were present in 6 cases; in 4 cases a fracture was the mode of presentation. Seven patients had metastases (4 involving bone) at the time of presentation. Only one patient is still alive after 5 years. In the 10 patients who died as a direct result of the tumor, death occured on average 8 months following diagnosis if metastases were present initially, and 36 months after the diagnosis otherwise. Tumors predominantly involved the leg (7 cases), the pelvis (2 cases), and the humerus (2 cases), the involvement being both diaphyseal and metaphyseal. The radiologic appearance is that of an aggressive, poorly demarcated tumor, with cortical destruction, periosteal reaction and soft tissue invasion. Comparison with Ewing sarcoma shows little radiologic or clinical difference, except for a poorer prognosis in neuroectodermal bone tumors. Both bone tumors may have a similar neuroectodermal origin, with Ewing sarcoma representing the undifferentiated variety.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalSkeletal Radiology
Volume18
Issue number2
DOIs
Publication statusPublished - Apr 1989

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Neuroectodermal Tumors
Bone and Bones
Ewing's Sarcoma
Neoplasms
Neoplasm Metastasis
Humerus
Pelvis
Leg
Fever

Keywords

  • Bone neoplasms
  • Ewing sarcoma
  • Neuroepithelioma
  • Primary neuro-ectodermal tumors
  • Round cell tumor

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Rousselin, B., Vanel, D., Terrier-Lacombe, M. J., Istria, B. J. M., Spielman, M., & Masselot, J. (1989). Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone. Skeletal Radiology, 18(2), 115-120. https://doi.org/10.1007/BF00350659

Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone. / Rousselin, B.; Vanel, D.; Terrier-Lacombe, M. J.; Istria, B. J M; Spielman, M.; Masselot, J.

In: Skeletal Radiology, Vol. 18, No. 2, 04.1989, p. 115-120.

Research output: Contribution to journalArticle

Rousselin, B, Vanel, D, Terrier-Lacombe, MJ, Istria, BJM, Spielman, M & Masselot, J 1989, 'Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone', Skeletal Radiology, vol. 18, no. 2, pp. 115-120. https://doi.org/10.1007/BF00350659
Rousselin B, Vanel D, Terrier-Lacombe MJ, Istria BJM, Spielman M, Masselot J. Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone. Skeletal Radiology. 1989 Apr;18(2):115-120. https://doi.org/10.1007/BF00350659
Rousselin, B. ; Vanel, D. ; Terrier-Lacombe, M. J. ; Istria, B. J M ; Spielman, M. ; Masselot, J. / Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone. In: Skeletal Radiology. 1989 ; Vol. 18, No. 2. pp. 115-120.
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