Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: Prospective evaluation in a large cohort of Italian patients

R. Gerli, L. Caponi, A. Tincani, R. Scorza, M. G. Sabbadini, M. G. Danieli, V. De Angelis, M. Cesarotti, M. Piccirilli, R. Quartesan, P. Moretti, C. Cantoni, F. Franceschini, I. Cavazzana, L. Origgi, M. Vanoli, E. Bozzolo, L. Ferrario, A. Padovani, O. GambiniL. Vanzulli, D. Croce, S. Bombardieri

Research output: Contribution to journalArticle

Abstract

Objective. To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE). Methods. Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions. Results. Serum anti-P were detected in 18/149 patients (12.1%). The anti-P prevalence was similar (11.7%) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment. Conclusion. This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset.

Original languageEnglish
Pages (from-to)1357-1366
Number of pages10
JournalRheumatology
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

Fingerprint

Systemic Lupus Erythematosus
Autoantibodies
Central Nervous System Lupus Vasculitis
Serum
Enzyme-Linked Immunosorbent Assay
Skin Manifestations
Anticardiolipin Antibodies
Rheumatology
Exanthema
Terminology
Epitopes
Anti-Idiotypic Antibodies
Immunoglobulin G
Antigens
Peptides

Keywords

  • Anti-P-antibodies
  • Anticardiolipin antibodies
  • Neuropsychiatric lupus
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus : Prospective evaluation in a large cohort of Italian patients. / Gerli, R.; Caponi, L.; Tincani, A.; Scorza, R.; Sabbadini, M. G.; Danieli, M. G.; De Angelis, V.; Cesarotti, M.; Piccirilli, M.; Quartesan, R.; Moretti, P.; Cantoni, C.; Franceschini, F.; Cavazzana, I.; Origgi, L.; Vanoli, M.; Bozzolo, E.; Ferrario, L.; Padovani, A.; Gambini, O.; Vanzulli, L.; Croce, D.; Bombardieri, S.

In: Rheumatology, Vol. 41, No. 12, 01.12.2002, p. 1357-1366.

Research output: Contribution to journalArticle

Gerli, R, Caponi, L, Tincani, A, Scorza, R, Sabbadini, MG, Danieli, MG, De Angelis, V, Cesarotti, M, Piccirilli, M, Quartesan, R, Moretti, P, Cantoni, C, Franceschini, F, Cavazzana, I, Origgi, L, Vanoli, M, Bozzolo, E, Ferrario, L, Padovani, A, Gambini, O, Vanzulli, L, Croce, D & Bombardieri, S 2002, 'Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: Prospective evaluation in a large cohort of Italian patients', Rheumatology, vol. 41, no. 12, pp. 1357-1366. https://doi.org/10.1093/rheumatology/41.12.1357
Gerli, R. ; Caponi, L. ; Tincani, A. ; Scorza, R. ; Sabbadini, M. G. ; Danieli, M. G. ; De Angelis, V. ; Cesarotti, M. ; Piccirilli, M. ; Quartesan, R. ; Moretti, P. ; Cantoni, C. ; Franceschini, F. ; Cavazzana, I. ; Origgi, L. ; Vanoli, M. ; Bozzolo, E. ; Ferrario, L. ; Padovani, A. ; Gambini, O. ; Vanzulli, L. ; Croce, D. ; Bombardieri, S. / Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus : Prospective evaluation in a large cohort of Italian patients. In: Rheumatology. 2002 ; Vol. 41, No. 12. pp. 1357-1366.
@article{895dd7b193c242ce83412137fbc0b7d3,
title = "Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: Prospective evaluation in a large cohort of Italian patients",
abstract = "Objective. To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE). Methods. Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions. Results. Serum anti-P were detected in 18/149 patients (12.1{\%}). The anti-P prevalence was similar (11.7{\%}) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment. Conclusion. This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset.",
keywords = "Anti-P-antibodies, Anticardiolipin antibodies, Neuropsychiatric lupus, Systemic lupus erythematosus",
author = "R. Gerli and L. Caponi and A. Tincani and R. Scorza and Sabbadini, {M. G.} and Danieli, {M. G.} and {De Angelis}, V. and M. Cesarotti and M. Piccirilli and R. Quartesan and P. Moretti and C. Cantoni and F. Franceschini and I. Cavazzana and L. Origgi and M. Vanoli and E. Bozzolo and L. Ferrario and A. Padovani and O. Gambini and L. Vanzulli and D. Croce and S. Bombardieri",
year = "2002",
month = "12",
day = "1",
doi = "10.1093/rheumatology/41.12.1357",
language = "English",
volume = "41",
pages = "1357--1366",
journal = "Rheumatology",
issn = "1462-0324",
publisher = ". Published by Oxford University Press on behalf of the British Society for Rheumatology",
number = "12",

}

TY - JOUR

T1 - Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus

T2 - Prospective evaluation in a large cohort of Italian patients

AU - Gerli, R.

AU - Caponi, L.

AU - Tincani, A.

AU - Scorza, R.

AU - Sabbadini, M. G.

AU - Danieli, M. G.

AU - De Angelis, V.

AU - Cesarotti, M.

AU - Piccirilli, M.

AU - Quartesan, R.

AU - Moretti, P.

AU - Cantoni, C.

AU - Franceschini, F.

AU - Cavazzana, I.

AU - Origgi, L.

AU - Vanoli, M.

AU - Bozzolo, E.

AU - Ferrario, L.

AU - Padovani, A.

AU - Gambini, O.

AU - Vanzulli, L.

AU - Croce, D.

AU - Bombardieri, S.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Objective. To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE). Methods. Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions. Results. Serum anti-P were detected in 18/149 patients (12.1%). The anti-P prevalence was similar (11.7%) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment. Conclusion. This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset.

AB - Objective. To verify the association of ribosomal anti-P antibodies (anti-P), as detected by a sensitive ELISA, with serological findings and clinical manifestations, including neuropsychiatric involvement evaluated according to the American College of Rheumatology (ACR) nomenclature, in a large cohort of patients with systemic lupus erythematosus (SLE). Methods. Anti-P were evaluated in the serum of 149 consecutive Italian SLE patients by an ELISA using a multiple antigen peptide carrying four copies of a common P0, P1 and P2 epitope. A complete laboratory evaluation and clinical examination were performed in each patient. In addition, all patients underwent an accurate neuropsychiatric and neuropsychological assessment performed by trained specialists according to the 1999 ACR suggestions. Results. Serum anti-P were detected in 18/149 patients (12.1%). The anti-P prevalence was similar (11.7%) when the analysis was performed in a larger series of sera including 82 additional SLE patients, who were not included in the clinical study. The age of anti-P-positive patients at disease onset was less than 33 yr and, in comparison with the anti-P-negative patients, these patients showed more active disease activity and a higher prevalence of photosensitivity and malar and discoid rash. A strong association between IgG anticardiolipin antibodies and anti-P was also found. However, anti-P were associated with neither neuropsychiatric syndromes nor cognitive impairment. Conclusion. This study does not seem to confirm the described association of anti-P with SLE neuropsychiatric manifestations. However, it supports the anti-P association with different skin manifestations as well as the presence of anticardiolipin in a subset of patients with SLE characterized by early disease onset.

KW - Anti-P-antibodies

KW - Anticardiolipin antibodies

KW - Neuropsychiatric lupus

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=0036905617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036905617&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/41.12.1357

DO - 10.1093/rheumatology/41.12.1357

M3 - Article

C2 - 12468814

AN - SCOPUS:0036905617

VL - 41

SP - 1357

EP - 1366

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 12

ER -