Clinical and technical feasibility of ultra-boost irradiation in dominant intraprostatic Lesion by Tomotherapy: Preliminary experience and revision of literature

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Abstract

BACKGROUND: The aim of this paper was to present our experience of dominant intraprostatic lesions (DIL) irradiation up to an eQd2 of 93,2 Gy with helical tomotherapy. Methods: Between march 2012 and december 2014, 15 staged ii-iii patients with intermediate-high risk prostate cancer were enrolled in our protocol of DIL dose escalation by Tomotherapy. all patients were submitted to a multiparametric MRI (including DCE and DWI series), in order to visualize DILs. Considering a mean α/beta; ratio of 3 for prostate cancer the prescribed doses were: 83.2 Gy in 32 fractions of 2.6 per fraction (eQd2=93.2 Gy) on the DILs, 75.2 Gy in 32 fractions of 2.35 Gy per fraction (eQd2=80.5 Gy) on the prostate gland and 67.2 Gy in 32 fraction of 2.1 (eQd2=68.5 Gy) on the seminal vesicles. Results: With a mean follow-up of 16 months (range 2-39), no overall severe acute toxicities >G3 were observed; one patient out of 15 (6.6%) had acute gastrointestinal (Gi) toxicity equal to G2, while two cases (13.3%) had G2 acute genitourinary (GU) toxicity. no >G2 late toxicity was observed. at last follow-up, for all patients, the biochemical disease free survival was 100%. Conclusions: The irradiation of the whole prostate and seminal vesicles up to an eQd2 of 80.5 Gy and of DILs up to 93.2 Gy was clinically feasible and safe, without acute severe toxicity. although with a short follow-up, late toxicities are currently absent and no patient relapsed.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalPanminerva Medica
Volume58
Issue number1
Publication statusPublished - Mar 1 2016

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Seminal Vesicles
Prostate
Prostatic Neoplasms
Intensity-Modulated Radiotherapy
Disease-Free Survival

Keywords

  • Feasibility studies
  • Prostatic neoplasms
  • Radiotherapy, intensity-modulated

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{25524494d98246f3ade47303792461b9,
title = "Clinical and technical feasibility of ultra-boost irradiation in dominant intraprostatic Lesion by Tomotherapy: Preliminary experience and revision of literature",
abstract = "BACKGROUND: The aim of this paper was to present our experience of dominant intraprostatic lesions (DIL) irradiation up to an eQd2 of 93,2 Gy with helical tomotherapy. Methods: Between march 2012 and december 2014, 15 staged ii-iii patients with intermediate-high risk prostate cancer were enrolled in our protocol of DIL dose escalation by Tomotherapy. all patients were submitted to a multiparametric MRI (including DCE and DWI series), in order to visualize DILs. Considering a mean α/beta; ratio of 3 for prostate cancer the prescribed doses were: 83.2 Gy in 32 fractions of 2.6 per fraction (eQd2=93.2 Gy) on the DILs, 75.2 Gy in 32 fractions of 2.35 Gy per fraction (eQd2=80.5 Gy) on the prostate gland and 67.2 Gy in 32 fraction of 2.1 (eQd2=68.5 Gy) on the seminal vesicles. Results: With a mean follow-up of 16 months (range 2-39), no overall severe acute toxicities >G3 were observed; one patient out of 15 (6.6{\%}) had acute gastrointestinal (Gi) toxicity equal to G2, while two cases (13.3{\%}) had G2 acute genitourinary (GU) toxicity. no >G2 late toxicity was observed. at last follow-up, for all patients, the biochemical disease free survival was 100{\%}. Conclusions: The irradiation of the whole prostate and seminal vesicles up to an eQd2 of 80.5 Gy and of DILs up to 93.2 Gy was clinically feasible and safe, without acute severe toxicity. although with a short follow-up, late toxicities are currently absent and no patient relapsed.",
keywords = "Feasibility studies, Prostatic neoplasms, Radiotherapy, intensity-modulated",
author = "Elisabetta Garibaldi and Elena Delmastro and Domenico Gabriele and Sara Bresciani and Filippo Russo and {Di Dia}, Amalia and Gabriella Cattari and Gaetano Belli and Pietro Gabriele",
year = "2016",
month = "3",
day = "1",
language = "English",
volume = "58",
pages = "16--22",
journal = "Panminerva Medica",
issn = "0031-0808",
publisher = "Edizioni Minerva Medica S.p.A.",
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TY - JOUR

T1 - Clinical and technical feasibility of ultra-boost irradiation in dominant intraprostatic Lesion by Tomotherapy

T2 - Preliminary experience and revision of literature

AU - Garibaldi, Elisabetta

AU - Delmastro, Elena

AU - Gabriele, Domenico

AU - Bresciani, Sara

AU - Russo, Filippo

AU - Di Dia, Amalia

AU - Cattari, Gabriella

AU - Belli, Gaetano

AU - Gabriele, Pietro

PY - 2016/3/1

Y1 - 2016/3/1

N2 - BACKGROUND: The aim of this paper was to present our experience of dominant intraprostatic lesions (DIL) irradiation up to an eQd2 of 93,2 Gy with helical tomotherapy. Methods: Between march 2012 and december 2014, 15 staged ii-iii patients with intermediate-high risk prostate cancer were enrolled in our protocol of DIL dose escalation by Tomotherapy. all patients were submitted to a multiparametric MRI (including DCE and DWI series), in order to visualize DILs. Considering a mean α/beta; ratio of 3 for prostate cancer the prescribed doses were: 83.2 Gy in 32 fractions of 2.6 per fraction (eQd2=93.2 Gy) on the DILs, 75.2 Gy in 32 fractions of 2.35 Gy per fraction (eQd2=80.5 Gy) on the prostate gland and 67.2 Gy in 32 fraction of 2.1 (eQd2=68.5 Gy) on the seminal vesicles. Results: With a mean follow-up of 16 months (range 2-39), no overall severe acute toxicities >G3 were observed; one patient out of 15 (6.6%) had acute gastrointestinal (Gi) toxicity equal to G2, while two cases (13.3%) had G2 acute genitourinary (GU) toxicity. no >G2 late toxicity was observed. at last follow-up, for all patients, the biochemical disease free survival was 100%. Conclusions: The irradiation of the whole prostate and seminal vesicles up to an eQd2 of 80.5 Gy and of DILs up to 93.2 Gy was clinically feasible and safe, without acute severe toxicity. although with a short follow-up, late toxicities are currently absent and no patient relapsed.

AB - BACKGROUND: The aim of this paper was to present our experience of dominant intraprostatic lesions (DIL) irradiation up to an eQd2 of 93,2 Gy with helical tomotherapy. Methods: Between march 2012 and december 2014, 15 staged ii-iii patients with intermediate-high risk prostate cancer were enrolled in our protocol of DIL dose escalation by Tomotherapy. all patients were submitted to a multiparametric MRI (including DCE and DWI series), in order to visualize DILs. Considering a mean α/beta; ratio of 3 for prostate cancer the prescribed doses were: 83.2 Gy in 32 fractions of 2.6 per fraction (eQd2=93.2 Gy) on the DILs, 75.2 Gy in 32 fractions of 2.35 Gy per fraction (eQd2=80.5 Gy) on the prostate gland and 67.2 Gy in 32 fraction of 2.1 (eQd2=68.5 Gy) on the seminal vesicles. Results: With a mean follow-up of 16 months (range 2-39), no overall severe acute toxicities >G3 were observed; one patient out of 15 (6.6%) had acute gastrointestinal (Gi) toxicity equal to G2, while two cases (13.3%) had G2 acute genitourinary (GU) toxicity. no >G2 late toxicity was observed. at last follow-up, for all patients, the biochemical disease free survival was 100%. Conclusions: The irradiation of the whole prostate and seminal vesicles up to an eQd2 of 80.5 Gy and of DILs up to 93.2 Gy was clinically feasible and safe, without acute severe toxicity. although with a short follow-up, late toxicities are currently absent and no patient relapsed.

KW - Feasibility studies

KW - Prostatic neoplasms

KW - Radiotherapy, intensity-modulated

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